%0 Journal Article
%T PTP1B Inhibition Improves Mitochondrial Dynamics to Alleviate Calcific Aortic Valve Disease Via Regulating OPA1 Homeostasis.
%A Liu F
%A Chen J
%A Hu W
%A Gao C
%A Zeng Z
%A Cheng S
%A Yu K
%A Qian Y
%A Xu D
%A Zhu G
%A Zhao J
%A Liu X
%A Wang J
%A Liu F
%A Chen J
%A Hu W
%A Gao C
%A Zeng Z
%A Cheng S
%A Yu K
%A Qian Y
%A Xu D
%A Zhu G
%A Zhao J
%A Liu X
%A Wang J
%J JACC Basic Transl Sci
%V 7
%N 7
%D Jul 2022
%M 35958694
%F 9.531
%R 10.1016/j.jacbts.2022.03.002
%X There are currently no pharmacological therapies for calcific aortic valve disease (CAVD). Here, we evaluated the role of protein tyrosine phosphatase 1B (PTP1B) inhibition in CAVD. Up-regulation of PTP1B was critically involved in calcified human aortic valve, and PTP1B inhibition had beneficial effects in preventing fibrocalcific response in valvular interstitial cells and LDLR-/- mice. In addition, we reported a novel function of PTP1B in regulating mitochondrial homeostasis by interacting with the OPA1 isoform transition in valvular interstitial cell osteogenesis. Thus, these findings have identified PTP1B as a potential target for preventing aortic valve calcification in patients with CAVD.