Abstract：
Bioactive peptides from food have been widely studied due to their potential applications as functional foods and pharmaceuticals. Sea cucumber, a traditional tonic food, is characterized by high protein and low fat, thereby substrates are being studied to release sea cucumber peptides (SCPs). Although recent studies have shown that SCPs have various bioactive functions, there is no literature reviewing the development status of SCPs. In this review, we summarized the production of SCPs, including their purification and identification, then mainly focused on the comprehensive potential health benefits of SCP in vivo and in vitro, and finally discussed the challenge facing the development of SCPs. We found that SCPs have well-documented health benefits due to their antioxidation, anti-diabetes, ACE inhibitory, immunomodulatory, anti-cancer, anti-fatigue, anti-aging, neuroprotection, micromineral-chelating, etc. However, the structure-activity relationships of SCPs and the functional molecular mechanisms underlying their regulation in vivo need further investigation. Research on the safety of SCP and its potential regulation mechanism will contribute to transferring these findings into commercial applications. Hopefully, this review could promote the development and application of SCPs in further investigation and commercialization.
摘要：
来自食品的生物活性肽由于其作为功能性食品和药物的潜在应用而被广泛研究。海参,传统的滋补食品，其特点是高蛋白和低脂肪，因此，正在研究释放海参肽（SCP）的底物。尽管最近的研究表明SCP具有多种生物活性功能，目前尚无文献回顾SCP的发展现状。在这次审查中,我们总结了SCP的生产，包括它们的净化和鉴定，然后主要关注SCP在体内和体外的综合潜在健康益处，最后讨论了SCP发展面临的挑战。我们发现SCP由于其抗氧化作用而对健康有益，抗糖尿病,ACE抑制性,免疫调节,抗癌，抗疲劳,抗衰老,神经保护,微矿物螯合，等。然而,SCP的构效关系及其在体内调控的功能分子机制需要进一步研究.对SCP安全性及其潜在调节机制的研究将有助于将这些发现转化为商业应用。希望,这项审查可以促进SCP在进一步调查和商业化中的开发和应用。
