线粒体复合物 I 作为阿尔茨海默病的治疗靶点。
关键词: AD, Alzheimer's disease ADP, adenosine diphosphate AIDS, acquired immunodeficiency syndrome AMP, adenosine monophosphate AMPK, AMP-activated protein kinase APP/PS1, amyloid precursor protein/presenilin 1 ATP, adenosine triphosphate Alzheimer's disease Aβ, amyloid beta BBB, blood‒brain barrier BDNF, brain-derived neurotrophic factor CP2, tricyclic pyrone compound two Complex I inhibitors ER, endoplasmic reticulum ETC, electron transport chain FADH2, flavin adenine dinucleotide FDG-PET, fluorodeoxyglucose-positron emission tomography GWAS, genome-wide association study HD, Huntington's disease HIF-1α, hypoxia induced factor 1 α Healthy aging ISR, integrated stress response Integrated stress response LTP, long term potentiation MCI, mild cognitive impairment MPTP, 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine Mitochondria Mitochondria signaling Mitochondria targeted therapeutics NAD+ and NADH, nicotinamide adenine dinucleotide NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells NRF2, nuclear factor E2-related factor 2 Neuroprotection OXPHOS, oxidative phosphorylation PD, Parkinson's disease PGC1α, peroxisome proliferator-activated receptor gamma coactivator 1 alpha PMF, proton-motive force RNAi, RNA interference ROS, reactive oxygen species T2DM, type II diabetes mellitus TCA, the tricarboxylic acid cycle mtDNA, mitochondrial DNA mtUPR, mitochondrial unfolded protein response pTau, hyper-phosphorylated Tau protein ΔpH, proton gradient Δψm, mitochondrial membrane potential
来 源:
DOI:10.1016/j.apsb.2021.11.003
PDF(Pubmed)