未经证实:大量证据表明植物药在应激相关疾病中的有效性。Kamikihito(KKT),日本传统草药(Kampo),用于贫血,失眠,和焦虑。最近的研究表明,它对几种动物模型的认知和记忆功能障碍有改善作用。我们,因此,确定每天补充KKT对大鼠应激诱导的行为和神经系统变化是否具有抗抑郁样作用。
UNASSIGNED:使用慢性束缚应激(CRS)大鼠模型确定了KKT对应激诱导的焦虑和抑郁样行为以及海马神经发生的影响。在连续21天的CRS(6小时/天)期间,每天口服施用300或1000mg/kg的KKT。CRS和KKT对生理参数的影响,包括体重增加,食物/水的消耗,血浆皮质酮(CORT)水平,肾上腺重量占体重的百分比,首先测量。在开放场测试(OFT)中评估了大鼠的焦虑和抑郁样行为,蔗糖偏好测试(SPT),强迫游泳试验(FST)。通过免疫组织化学确定海马神经发生。
UNASSIGNED:CRS持续21天导致体重增加显着降低,血浆CORT水平和肾上腺重量占体重的百分比增加,通过KKT治疗获救。KKT还抑制CRS诱导的焦虑和抑郁样行为以及海马神经发生的损害。这些结果表明,KKT的日常治疗具有对生理保护作用,神经学,和抑郁症大鼠模型的行为变化。
UNASSIGNED: Substantial evidence suggests the effectiveness of plant-based medicine in stress-related diseases. Kamikihito (KKT), a Japanese traditional herbal medicine (Kampo), has been used for anemia, insomnia, and anxiety. Recent studies revealed its ameliorating effect on cognitive and memory dysfunction in several animal models. We, therefore, determined whether daily supplementation of KKT has an antidepressant-like effect on the stress-induced behavioral and neurological changes in rats.
UNASSIGNED: The effect of KKT against the stress-induced changes in anxiety- and depressive-like behaviors and hippocampal neurogenesis were determined using a rat model of chronic restraint stress (CRS). KKT was orally administered daily at 300 or 1000 mg/kg during 21 consecutive days of CRS (6 h/day). The effect of CRS and KKT on physiological parameters, including body weight gain, food/water consumptions, plasma corticosterone (CORT) levels, and percentage of adrenal gland weight to body weight, were firstly measured. Anxiety- and depressive-like behaviors in rats were assessed in the open field test (OFT), sucrose preference test (SPT), and forced swimming test (FST). Hippocampal neurogenesis was determined by immunohistochemistry.
UNASSIGNED: CRS for 21 days caused a significant decrease in body weight gain and increase in plasma CORT levels and percentage of adrenal gland weight to body weight, which were rescued by KKT treatment. KKT also suppressed the CRS-induced anxiety- and depressive-like behaviors and impairment of hippocampal neurogenesis. These results suggest that daily treatment of KKT has a protective effect against physiological, neurological, and behavioral changes in a rat model of depression.