沙门氏菌鞭毛通过激活肿瘤微环境中的鞭毛蛋白 / TLR5 信号传导赋予抗肿瘤免疫作用。
关键词: AKT, Akt serine/threonine kinase Bacteria-mediated cancer therapy CFU, colony-forming units CTLA-4, cytotoxic T-lymphocyte-associated protein 4 Cancer immune therapy DN, dominant-negative ERBB2, Erb-B2 receptor tyrosine kinase 2 ERKl, extracellular regulated protein kinase 1 Flagellin Flagellum GAPDH, glyceraldehyde-3-phosphate dehydrogenase GFP, green fluorescent protein IFN-γ, interferon-γ IL, interleukins IκB, inhibitor of NF-κB JNK, c-Jun N-terminal kinase LPS, lipopolysaccharide LRR, leucine-rich repeat MyD88, myeloid differentiation factor 88 NF-κB NF-κB, nuclear factor kappa-B PBS, phosphate-buffered saline PCR, polymerase chain reaction PD-1, programmed cell death protein-1 PD-L1, programmed cell death-ligand 1 PEI, polyethylenimine Salmonella TIR, Toll/Interleukin-1 receptor TLR, Toll-like receptor TLR5 TME, tumor microenvironment TRAF6, TNF receptor associated factor 6 VNP20009 i.p., intraperitoneally i.t., intratumorally
来 源:
DOI:10.1016/j.apsb.2021.04.019
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