未经证实:帕金森病(PD)的许多运动症状影响生活质量,目前的药物和手术治疗并没有完全改善。需要更好地了解这些症状背后的病理生理学。先前的研究表明,炎症可能在PD病理生理和进展中起重要作用,但是关于炎症与PD运动症状直接相关的研究有限。因此,这项研究的目的是评估外周免疫炎症标志物与PD运动症状之间的关系,具体来说,震颤,运动迟缓,姿势和步态不稳定。我们假设外周炎症细胞因子可以预测PD患者运动症状的严重程度,与年龄匹配的健康老年人相比,PD患者的外周炎性细胞因子标志物水平更高。
未经评估:26名PD患者和14名健康老年人完成了这项研究。对于PD的参与者,对帕金森病统一评定量表(UPDRS)的运动部分进行了记录,并由两名运动障碍神经科医师进行了评分.从患有PD的参与者和健康的老年人收集血液样本。通过MILLIPLEX®图谱高灵敏度人类细胞因子试剂盒,分析了关键的炎症相关标志物(TNF-α,IFN-γ,IL-1β,IL-8、IL-2、IL-7、IL-5、IL-13、4,IL-10,IL-12p70,GM-CSF,和IL-6)。
未经证实:结果显示,与健康老年人相比,PD患者的IL-6水平显着升高(p=0.005)。此外,结果显示,较高水平的IL-4(p=0.011)和较低水平的IFNγ(p=0.003)显着预测PD患者的震颤更严重。未观察到外周炎症标志物和其他运动症状之间的其他关联。
未经评估:总的来说,这些结果与越来越多的文献一致,这些文献涉及PD中的炎性细胞因子,并进一步表明炎症细胞因子,或缺乏,可能与PD患者的震颤有关。
UNASSIGNED: Many of the motor symptoms of Parkinson\'s disease (PD) impact quality of life and are not fully ameliorated by current pharmacological and surgical treatments. A better understanding of the pathophysiology underlying these symptoms is needed. Previous research has suggested that inflammation may play a significant role in PD pathophysiology and progression, but there is limited research exploring how inflammation directly relates to motor symptoms in PD. Thus, the purpose of this study was to evaluate associations between peripheral immune inflammatory markers and motor symptoms of PD, specifically, tremor, bradykinesia, and postural and gait instability. We hypothesized that peripheral inflammatory cytokines would predict the severity of motor symptoms in persons with PD, and that there will be higher levels of peripheral inflammatory cytokine markers in persons with PD when compared to age-matched healthy older adults.
UNASSIGNED: Twenty-six participants with PD and fourteen healthy older adults completed the study. For participants with PD, the motor section of the Unified Parkinson\'s Disease Rating Scale (UPDRS) was recorded and scored by two Movement Disorders Neurologists masked to the study. A blood sample was collected from both participants with PD and the healthy older adults. Through the MILLIPLEX® map High Sensitivity Human Cytokine Kit, key inflammation-related markers were analyzed (TNF-α, IFN-γ, IL-1β, IL-8, IL-2, IL-7, IL-5, IL-13, IL, 4, IL-10 IL-12p70, GM-CSF, and IL-6).
UNASSIGNED: Results revealed significantly higher levels of IL-6 in persons with PD when compared to healthy older adults (p = 0.005). Moreover, results revealed that higher levels of IL-4 (p = 0.011) and lower levels of IFNγ (p = 0.003) significantly predicted more severe tremor in persons with PD. No other associations between the peripheral inflammation markers and other motor symptoms were observed.
UNASSIGNED: Overall, these results are consistent with a growing body of literature that implicates inflammatory cytokines in the PD, and further suggests that inflammatory cytokines, or lack thereof, may be associated with tremor in persons with PD.