DNA 损伤应答途径的改变 : 肿瘤免疫治疗的生物标志物和治疗策略。
关键词: ATM, ataxia-telangiectasia mutated ATR, ataxia telangiectasia and Rad3 related BAP1, BRCA1-associated protein 1 BER, base excision repair BRAF, v-RAF murine sarcoma viral oncogene homologue B BRCA, breast cancer susceptibility gene CHEK, cell-cycle checkpoint kinase CHK1, checkpoint kinase 1 DAMP, damage-associated molecular patterns DDR, DNA damage response DNA damage response DNA repair DR, direct repair DSBs, double-strand breaks FDA, United State Food and Drug Administration GSK3β, glycogen synthase kinase 3β Genomic instability HMGB1, high mobility group box-1 HRR, homologous recombination repair ICI, immune checkpoint inhibitor IFNγ, interferon gamma IHC, immunohistochemistry IRF1, interferon regulatory factor 1 Immunotherapy JAK, Janus kinase MAD1, mitotic arrest deficient-like 1 MGMT, O6-methylguanine methyltransferase MLH1, MutL homolog 1 MMR, mismatch repair MNT, MAX network transcriptional repressor MSH2/6, MutS protein homologue-2/6 MSI, microsatellite instability MUTYH, MutY homolog MyD88, myeloid differentiation factor 88 NEK1, NIMA-related kinase 1 NER, nucleotide excision repair NGS, next generation sequencing NHEJ, nonhomologous end-joining NIMA, never-in-mitosis A NSCLC, non-small cell lung cancer ORR, objective response rate OS, overall survival PALB2, partner and localizer of BRCA2 PARP, poly-ADP ribose polymerase PCR, polymerase chain reaction PD-1 PD-1, programmed death 1 PD-L1 PD-L1, programmed death ligand 1 PFS, progression-free survival RAD51C, RAD51 homolog C RB1, retinoblastoma 1 RPA, replication protein A RSR, replication stress response SCNAs, somatic copy number alterations STAT, signal transducer and activator of transcription STING, stimulator of interferon genes TBK1, TANK-binding kinase 1 TILs, tumor-infiltrating lymphocytes TLR4, Toll-like receptor 4 TMB, tumor mutational burden TME, tumor microenvironment TP53, tumor protein P53 TRIF, Toll-interleukin 1 receptor domain-containing adaptor inducing INF-β Tumor microenvironment XRCC4, X-ray repair cross complementing protein 4 cGAS, cyclic GMP–AMP synthase cGAS–STING ssDNA, single-stranded DNA
来 源:
DOI:10.1016/j.apsb.2021.01.003
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