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Abstract：
Ribosomal RNA is a major component of the ribosome. This RNA plays a crucial role in ribosome functioning by ensuring the formation of the peptide bond between amino acids and the accurate decoding of the genetic code. The rRNA carries many chemical modifications that participate in its maturation, the formation of the ribosome and its functioning. In this review, we present the different modifications and how they are deposited on the rRNA. We also describe the most recent results showing that the modified positions are not 100% modified, which creates a heterogeneous population of ribosomes. This gave rise to the concept of specialized ribosomes that we discuss. The knowledge accumulated in the yeast Saccharomyces cerevisiae is very helpful to better understand the role of rRNA modifications in humans, especially in ribosomopathies.
摘要：
核糖体RNA是核糖体的主要组分。这种RNA通过确保氨基酸之间肽键的形成和遗传密码的准确解码，在核糖体功能中起着至关重要的作用。rRNA携带许多参与其成熟的化学修饰，核糖体的形成及其功能。在这次审查中,我们介绍了不同的修饰以及它们如何在rRNA上沉积。我们还描述了最新的结果表明，修改后的位置不是100%修改，这产生了一个异质的核糖体群体。这产生了我们讨论的专门核糖体的概念。在酿酒酵母中积累的知识对于更好地理解rRNA修饰在人类中的作用非常有帮助，尤其是核糖体病。
