PDF(Sci-hub)
Abstract：
The aquatic environment receives a wide variety of contaminants that interact with each other, influencing their mutual toxicity. Therefore, studies of mixtures are needed to fully understand their deleterious effects on aquatic organisms. In the present experiment, we aimed to assess the effects of Cd and Zn mixtures in common carp during a one-week exposure. The used nominal waterborne metal levels were 0.02, 0.05 and 0.10 µM for Cd and 3, 7.5 and 15 µM for Zn. Our results showed on the one hand a fast Cd increase and on the other hand a delayed Zn accumulation. In the mixture scenario an inhibition of Cd accumulation due to Zn was marked in the liver but temporary in the gills. For Zn, the delayed accumulation gives an indication of the efficient homeostasis of this essential metal. Between the different mixtures, a stimulation of Zn accumulation by Cd rather than an inhibition was seen in the highest metal mixtures. However, when compared to an earlier single Zn exposure, a reduced Zn accumulation was observed. Metallothionein gene expression was quickly activated in the analysed tissues suggesting that the organism promptly responded to the stressful situation. Finally, the metal mixture did not alter tissue electrolyte levels.
摘要：
水生环境接收各种各样的污染物，这些污染物相互作用，影响它们的相互毒性。因此,需要对混合物进行研究，以充分了解它们对水生生物的有害影响。在本实验中,我们的目的是评估Cd和Zn混合物对鲤鱼在一周暴露期间的影响。使用的标称水性金属含量对于Cd为0.02、0.05和0.10µM，对于Zn为3、7.5和15µM。我们的结果表明，一方面Cd的快速增加，另一方面Zn的积累延迟。在混合物的情况下，由于锌而引起的Cd积累的抑制作用在肝脏中得到了明显的体现，但在the中却是暂时的。对于Zn，延迟的积累表明了这种必需金属的有效稳态。在不同的混合物之间，在最高的金属混合物中，可以看到Cd对Zn积累的刺激而不是抑制作用。然而,与早期的单一锌暴露相比，观察到Zn积累减少。在分析的组织中，金属硫蛋白基因表达迅速被激活，表明该生物对压力情况迅速做出反应。最后,金属混合物不会改变组织电解质水平.
