Defense mechanisms

防御机制
  • 文章类型: Journal Article
    活性氧(ROS)在植物病毒与其宿主植物之间的相互作用中起着复杂的作用。它们既可以帮助植物防御病毒感染,又可以支持病毒感染和传播。这篇综述探讨了ROS在植物-病毒相互作用中的各种作用,重点关注它们参与症状发展和植物防御机制的激活。本文讨论了ROS如何直接抑制病毒感染,以及它们如何通过涉及miRNA的各种途径调节抗病毒机制,病毒来源的小干扰RNA,病毒蛋白,和宿主蛋白。此外,它研究了ROS如何通过与激素途径和外部物质相互作用来增强植物抗性。该综述还考虑了ROS如何促进病毒感染和传播,强调它们在植物病毒动力学中的复杂作用。这些见解为未来的研究提供了宝贵的指导,例如通过基因工程探索ROS相关基因表达的操纵,开发生物农药,和调整环境条件以提高植物对病毒的抗性。该框架可以推进植物抗病性研究,农业实践,和疾病控制。
    Reactive oxygen species (ROS) play a complex role in interactions between plant viruses and their host plants. They can both help the plant defend against viral infection and support viral infection and spread. This review explores the various roles of ROS in plant-virus interactions, focusing on their involvement in symptom development and the activation of plant defense mechanisms. The article discusses how ROS can directly inhibit viral infection, as well as how they can regulate antiviral mechanisms through various pathways involving miRNAs, virus-derived small interfering RNAs, viral proteins, and host proteins. Additionally, it examines how ROS can enhance plant resistance by interacting with hormonal pathways and external substances. The review also considers how ROS might promote viral infection and transmission, emphasizing their intricate role in plant-virus dynamics. These insights offer valuable guidance for future research, such as exploring the manipulation of ROS-related gene expression through genetic engineering, developing biopesticides, and adjusting environmental conditions to improve plant resistance to viruses. This framework can advance research in plant disease resistance, agricultural practices, and disease control.
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  • 文章类型: Journal Article
    在两项研究中,使用五个样本(N=1,850),我们研究了避免健康信息-故意不了解现有但不需要的个人健康信息的决定-是否起到了防御作用,并且可以与其他防御策略互换.我们通过检查健康信息回避与故意决策和反馈克减之间的关系来测试这一想法。在研究1中,我们通过实验证明,相对于对照组,已知可以减少防御性的情况-自我不确定性-降低了主动回避和反应性防御性。研究2证明,在四个样本中,对个人健康信息有更大防御倾向的人更有可能减损健康信息。这些结果与反馈克减代替避免反馈的决定的想法是一致的。一起,研究结果表明,避免健康信息可能是更广泛的自我保护系统的一部分,并且可以被其他有动机的自我保护策略所替代.
    Across two studies, using five samples (N = 1,850), we examined whether health information avoidance-the deliberate decision to remain ignorant of available but unwanted personal health information-serves a defensive purpose and is interchangeable with other defensive strategies. We tested this idea by examining the relationship between health information avoidance-both as a dispositional tendency and deliberate decision-and feedback derogation. In Study 1, we experimentally demonstrated that a situation known to reduce defensiveness-self-uncertainty-decreased both proactive avoidance and reactive defensiveness relative to a control group. Study 2 demonstrated, across four samples, that people with a greater defensive orientation toward personal health information were more likely to derogate health information. These results are consistent with the idea that feedback derogation replaced the decision to avoid feedback. Together, results suggest that health information avoidance is likely part of a broader self-protective system and is replaceable with other motivated self-protection strategies.
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  • 文章类型: Journal Article
    最近开发了防御机制评级量表-自我报告-30(DMRS-SR-30),以增加自我报告替代防御评估,反映了他们普遍接受的等级组织。在这项研究中,我们旨在研究土耳其语版本的DMRS-SR-30的心理测量特性和因子结构。样本由1.002名参与者组成,他们填写了一项调查,其中包括DMRS-SR-30,简要症状清单,以及通过定性对人格组织的盘点。验证性因素分析表明三因素结构(CFI=0.89,RMSEA=0.05),证实了DMRS理论框架具有相对可接受的拟合。防御类别和总量表得分显示出良好的可靠性(α值在0.64至0.89之间)。防御之间的相关性,症状,人格功能表现出良好的收敛效度和判别效度。具有临床意义的BSI评分(T评分≥63)的个体在DMRS-SR-30评分上与非临床范围内的个体不同。土耳其版本的DMRS-SR-30是一种可靠且有效的工具,可以自我评估防御机制的层次结构和整体防御功能。此外,当前的研究支持在与DMRS和DMRS-SR-30起源不同的语言和文化中防御的三方模型的有效性。
    The Defense Mechanisms Rating Scales-Self Report-30 (DMRS-SR-30) was recently developed to add a self-report alternative to the assessment of defenses, reflecting their generally accepted hierarchical organization. In this study, we aimed to examine psychometric properties and factor structure of the Turkish language version of the DMRS-SR-30. The sample consisted of 1.002 participants who filled out a survey comprising the DMRS-SR-30, the Brief Symptom Inventory, and the Inventory of Personality Organization through Qualtrics. Confirmatory Factor Analysis indicated a three-factor structure (CFI = 0.89, RMSEA = 0.05) that confirms the DMRS theoretical frame with a relatively acceptable fit. Defensive categories and total scale scores showed good to excellent reliability (α values ranging from 0.64 to 0.89). Correlations between defenses, symptoms, and personality functioning demonstrated good convergent and discriminant validity. The individuals with clinically significant BSI scores (T-score ≥ 63) differed on the DMRS-SR-30 scores from the individuals in the non-clinical range. The Turkish version of the DMRS-SR-30 is a reliable and valid instrument to self-assess the hierarchy of defense mechanisms and overall defensive functioning. Moreover, the current study supports the validity of the tripartite model of defenses in a language and culture different from the origins of the DMRS and DMRS-SR-30.
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  • 文章类型: Journal Article
    目的:已知边缘性人格障碍(BPD)与多种人格障碍(PD)具有共同特征,并表现出多种防御机制模式。为了增强我们对BPD的了解,将我们的重点从传统的分类诊断转移到与其他PD共享的维度特征是至关重要的,正如边缘人格组织(BPO)模型所暗示的那样。这种方法照亮了BPD特征的细微光谱,对其复杂性提供更深入的见解。虽然有研究调查了BPD与其他PD的共病,探索各种人格因素与BPD自身防御机制之间关系的研究很少。本研究旨在调查被诊断为BPD的个体中各种人格因素与防御方式之间的复杂相互关系。
    方法:使用网络分析方法,使用防御方式问卷和人格障碍问卷-4+对227例诊断为BPD的患者的数据进行评估。
    结果:在人格因素和防御方式之间观察到了错综复杂的联系。各种人格因素和防御风格之间存在显着关联,防御风格不成熟,例如,自适应不良和图像失真在中心性分析中在BPD中尤为突出。适应不良的防御方式具有最高的预期影响中心性。此外,分裂型,依赖,自恋人格因素在网络中表现出相对较高的中心性。
    结论:网络分析可以有效地描述各种PD和防御方式的复杂性。这些发现预计将有助于更深入地理解为什么BPD表现出不同的组织水平,并呈现出异质特征,与BPO提出的观点一致。
    OBJECTIVE: Borderline personality disorder (BPD) is known to share characteristics with a variety of personality disorders (PDs) and exhibits diverse patterns of defense mechanisms. To enhance our understanding of BPD, it\'s crucial to shift our focus from traditional categorical diagnostics to the dimensional traits shared with other PDs, as the borderline personality organization (BPO) model suggests. This approach illuminates the nuanced spectrum of BPD characteristics, offering deeper insights into its complexity. While studies have investigated the comorbidity of BPD with other PDs, research exploring the relationship between various personality factors and defense mechanisms within BPD itself has been scarce. The present study was undertaken to investigate the complex interrelationships between various personality factors and defense styles in individuals diagnosed with BPD.
    METHODS: Using a network analysis approach, data from 227 patients diagnosed with BPD were examined using the Defense Style Questionnaire and Personality Disorder Questionnaire-4+ for assessment.
    RESULTS: Intricate connections were observed between personality factors and defense styles. Significant associations were identified between various personality factors and defense styles, with immature defense styles, such as maladaptive and image-distorting being particularly prominent in BPD in the centrality analysis. The maladaptive defense style had the highest expected influence centrality. Furthermore, the schizotypal, dependent, and narcissistic personality factors demonstrated relatively high centrality within the network.
    CONCLUSIONS: Network analysis can effectively delineate the complexity of various PDs and defense styles. These findings are expected to facilitate a deeper understanding of why BPD exhibits various levels of organization and presents with heterogeneous characteristics, consistent with the perspectives proposed by the BPO.
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  • 文章类型: English Abstract
    同伴支持基于同伴照顾者和被支持者之间的镜像效应,这是一个强大的恢复杠杆。通过他们的工作,同伴助手还向“非同伴”照顾者举着镜子。他们看到的反思是一个试金石,可以导致护理实践的变化,但它也可以产生防御反应。
    Peer support is based on the mirror effect between the peer carer and the person being supported, which is a powerful lever for recovery. Through their work, peer helpers also hold up a mirror to \"non-peer\" carers. The reflection they see is a litmus test that can lead to changes in care practices, but it can also generate defensive reactions.
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  • 文章类型: Journal Article
    一些不良童年经历(ACE)的经历已被证明与青少年的创伤后应激障碍(PTSD)和自我组织障碍(DSO)症状有关。防御机制和应对方式是参与ACE与PTSD和DSO症状关联的心理过程。然而,缺乏关于法罗群岛青少年之间这些变量的联合关联的研究.
    这项研究的目的是通过防御机制和应对方式的间接影响,分析暴露于ACEs对PTSD和DSO症状的影响。
    从19所学校招募了687名法罗群岛青少年。参与者回答了经过验证的自我报告问卷。通过结构方程模型进行了多步骤调解和串行调解方法。
    通过不成熟防御机制的间接作用,暴露于ACE与PTSD和DSO症状有关,情绪应对,和超脱应对。通过合理应对,ACEs暴露与PTSD症状相关。
    结果表明,在应对青少年多重逆境中,防御机制与应对方式之间存在相互关系。
    UNASSIGNED: The experience of several adverse childhood experiences (ACEs) has been shown to be associated with Post-Traumatic Stress Disorder (PTSD) and Disturbances in Self-Organization (DSO) symptoms among adolescents. Defense mechanisms and coping styles are psychological processes involved in the association of ACEs with PTSD and DSO symptoms. However, there is a lack of research on the joint association of these variables among Faroese adolescents.
    UNASSIGNED: The aim of this study was to analyze the effect of exposure to ACEs on PTSD and DSO symptoms trough the indirect effect of defense mechanisms and coping styles in a sample of Faroese adolescents.
    UNASSIGNED: Six hundred and eighty-seven Faroese adolescents were recruited from 19 schools. Participants responded to validated self-report questionnaires. A multiple step mediation and a serial mediation methodology were conducted through structural equation modeling.
    UNASSIGNED: Exposure to ACEs was linked to PTSD and DSO symptoms through the indirect effect of immature defense mechanisms, emotional coping, and detachment coping. Exposure to ACEs was linked to PTSD symptoms through rational coping.
    UNASSIGNED: The results suggest a mutual relationship between defense mechanisms and coping styles in coping with multiple adversity among adolescents.
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  • 文章类型: Journal Article
    抗微生物细菌(AMR)的出现是世界范围内的主要健康问题之一。科学家们正在寻找一种治疗传染病的新方法。噬菌体疗法被认为是治疗传染病的合适方法。然而,这种方式有不同的挑战。一些生物学方面可能会影响治疗结果,需要进一步的研究才能成功进行噬菌体治疗。噬菌体活性可受细菌防御系统的影响。细菌胞外囊泡(BEV)是细菌防御机制之一,可以改变噬菌体活性的结果。BEV在基因转移中具有重要作用,入侵,逃跑,以及噬菌体的传播.在这次审查中,细菌对噬菌体的防御机制,尤其是BEV的分泌,BEV和噬菌体的隐藏联系,及其对噬菌体活性以及噬菌体疗法的可能影响将被讨论。
    Emergence of antimicrobial-resistant bacteria (AMR) is one of the health major problems worldwide. The scientists are looking for a novel method to treat infectious diseases. Phage therapy is considered a suitable approach for treating infectious diseases. However, there are different challenges in this way. Some biological aspects can probably influence on therapeutic results and further investigations are necessary to reach a successful phage therapy. Bacteriophage activity can influence by bacterial defense system. Bacterial extracellular vesicles (BEVs) are one of the bacterial defense mechanisms which can modify the results of bacteriophage activity. BEVs have the significant roles in the gene transferring, invasion, escape, and spreading of bacteriophages. In this review, the defense mechanisms of bacteria against bacteriophages, especially BEVs secretion, the hidden linkage of BEVs and bacteriophages, and its possible consequences on the bacteriophage activity as well phage therapy will be discussed.
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  • 文章类型: Journal Article
    防御机制(DMs)是个人用来保护自我的策略。因此,强迫症(OCD)中的强迫行为可以识别为DMs。我们分析了DMs在强迫症的简短认知行为疗法(CBT)中的变化。这是一项针对92名OCD患者(年龄18-60岁)的准实验研究。我们使用迷你国际神经精神病学访谈来确认强迫症的诊断,我们在三个时间点用国防风格问卷评估了DM。通过一个潜在的变化分数建模,我们发现,成熟的机制在治疗过程中呈现不断的变化。该机制在CBT的每个测量时刻平均增加0.37点,显示线性轨迹。神经和不成熟的机制在治疗期间没有显着变化。成熟机制的增加使用可以成为OCD治疗改善的指标,表明患者加强了对冲突的适应性反应。
    UNASSIGNED: Defense mechanisms (DMs) are strategies used by the individuals to protect the ego. Therefore, compulsive behaviors in obsessive-compulsive disorder (OCD) can be recognized as DMs. We analyzed how DMs changed in a brief cognitive behavioral therapy (CBT) for OCD. This was a quasi-experimental study with 92 OCD patients (aged 18-60 years). We used the Mini International Neuropsychiatric Interview to confirm OCD diagnosis, and we assessed the DMs with the Defense Style Questionnaire at three time points. Through a latent change score modeling, we found that the mature mechanism presented a constant change during the therapy. This mechanism increased in average 0.37 points at each measured moment of CBT, showing a linear trajectory. Neurotic and immature mechanisms showed no significant changes during therapy. The increased use of the mature mechanism can be an indicator of improvement in OCD treatment, showing that patients intensified their more adaptive responses to conflicts.
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  • 文章类型: Journal Article
    保护自己和他人的动机经常被视为相互矛盾的。这里,我们讨论了最近的证据,即实际上可以招募自卫机制来帮助他人。在某些情况下,在促进帮助方面,对威胁的防御性反应可能比对特定困境的反应更具决定性(正如移情-利他主义模型所预测的那样)。根据这些证据,我们认为,参与自卫的神经机制可能已经通过进化被重新利用,以保护他人,防御和护理可能是趋同的,而不是相互冲突的功能。最后,我们提出并讨论了与自我和他人防御有关的共享大脑机制的工作模型。
    The motivations to protect oneself and others have often been seen as conflicting. Here, we discuss recent evidence that self-defensive mechanisms may in fact be recruited to enable the helping of others. In some instances, the defensive response to a threat may even be more decisive in promoting helping than the response to a conspecific\'s distress (as predicted by empathy-altruism models). In light of this evidence, we propose that neural mechanisms implicated in self-defence may have been repurposed through evolution to enable the protection of others, and that defence and care may be convergent rather than conflicting functions. Finally, we present and discuss a working model of the shared brain mechanisms implicated in defence of both self and others.
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  • 文章类型: Journal Article
    1993年,《英国临床心理学杂志》发表了我的论文,题为“防御与安全:它们在社会行为和精神病理学中的作用”。这篇论文强调,要了解人们对威胁的敏感性,我们还需要了解他们识别什么是安全的能力。本文提供了对这些概念的更新,突出当时隐含但没有明确定义的区别。因此,本文旨在澄清以下方面的区别:(I)威胁检测和响应,(ii)安全和寻求安全,(iii)安全性和(iv)其社会和非社会功能和形式。威胁检测和响应是为了防止或最小化损害(例如,从捕食者或火灾中逃跑)。安全检查涉及监控是否存在和避免威胁,而安全寻求与防御行为目的地的联系(例如,runninghome).寻求安全还涉及对潜在危害的出现保持警惕,并采取据信可以避免伤害的措施。威胁防御和安全检查和寻求主要通过监控自然的进化威胁处理系统进行监管,存在,可控性和/或不存在威胁(例如,杏仁核和交感神经系统)。安全通过不同的心理生理系统使用不同的监测系统(例如,前额叶皮质,副交感神经系统)用于支持威胁应对的内部和外部资源的存在,冒险,资源勘探。创建招募安全处理的大脑状态可以影响标准的循证疗法(例如,暴露,痛苦容忍和重新评估)是有经验的,并产生长期的变化。
    In 1993, the British Journal of Clinical Psychology published my paper titled \'Defence and safety: Their function in social behaviour and psychopathology\'. The paper highlights that to understand people\'s sensitivity to threat, we also need to understand their ability to identify what is safe. This paper offers an update on these concepts, highlighting distinctions that were implicit but not clearly defined at the time. Hence, the paper seeks to clarify distinctions between: (i) threat detection and response, (ii) safety and safety seeking, (iii) safeness and (iv) their social and non-social functions and forms. Threat detection and response are to prevent or minimize harm (e.g., run from a predator or fire). Safety checking relates to monitoring for the absence and avoidance of threat, while safety seeking links to the destination of the defensive behaviour (e.g., running home). Safety seeking also relates to maintaining vigilance to the appearance of potential harms and doing things believed to avoid harm. Threat-defending and safety checking and seeking are regulated primarily through evolved threat processing systems that monitor the nature, presence, controllability and/or absence of threat (e.g., amygdala and sympathetic nervous system). Safeness uses different monitoring systems via different psychophysiological systems (e.g., prefrontal cortex, parasympathetic system) for the presence of internal and external resources that support threat-coping, risk-taking, resource exploration. Creating brain states that recruit safeness processing can impact how standard evidence-based therapies (e.g., exposure, distress tolerance and reappraisal) are experienced and produce long-term change.
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