Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar.

• 影响指数: 6.706
• 发表时间: Dec 2020 31
• 来源期刊: Nutrients
• DOI: 10.3390/nu13010127
• PMID: 33396346
• 文章类型: Journal Article
• 中科院分区: Q1
• 方向: 医学
• 作者列表: Mousa H,Islam N,Ganji V,Zughaier SM

关键词: 25-hydroxyvitamin D; HDL; MHR; inflammation; monocyte percentage; vitamin D

Mesh: Adult; Cardiometabolic Risk Factors; Cardiovascular Diseases / blood epidemiology immunology metabolism; Cholesterol, HDL / blood metabolism; Cross-Sectional Studies; Female; Humans; Inflammation / blood diagnosis immunology metabolism; Leukocyte Count; Lipid Metabolism / immunology; Male; Monocytes / immunology; Qatar / epidemiology; Retrospective Studies; Risk Assessment / methods; Vitamin D / analogs & derivatives blood; Vitamin D Deficiency / blood complications immunology metabolism; Young Adult

Abstract

Low serum 25-hydroxyvitamin D [25(OH)D] is linked to an altered lipid profile. Monocytes play an important role in inflammation and lipid metabolism. Recently, monocyte percentage to HDL-cholesterol ratio (MHR) has emerged as a novel marker of inflammation. We investigated the association between serum 25(OH)D concentrations and MHR and serum lipids in young healthy adults. Data from the Qatar Biobank were utilized to investigate the relation between serum 25(OH)D and inflammation and serum lipid concentrations in healthy Qatari adults using multivariate regression analysis. Prevalence of serum 25(OH)D concentrations <12 ng/mL (deficiency), 12-20 ng/mL (insufficiency), and ≥20 ng/mL (sufficiency) were 55.8%, 29.9%, and 14.3%, respectively. Serum 25(OH)D was significantly inversely associated with monocyte percentage, MHR, total cholesterol, LDL-cholesterol, and triacylglycerol in multivariable adjusted analysis. MHR could be a potential biomarker to predict cardiometabolic diseases among young healthy Qataris.