目的:本研究的主要目的是探讨成都地区医务人员中维生素D与单核细胞与HDL-C比值(MHR)的关系。中国。
方法:这项横断面研究涉及538名医务人员,包括393名女性和145名男性,包括性别数据,年龄,身体质量指数,和实验室参数(包括全血细胞计数,维生素D水平,脂质,等。).根据血清25(OH)D<20ng/ml作为维生素D缺乏,根据血清25(OH)D水平将受试者分为两组:血清25(OH)D<20ng/ml的维生素D缺乏组和血清25(OH)D≥20ng/ml的维生素D充足组.当考虑维生素D作为分类变量时,采用多变量logistic回归分析评估与维生素D缺乏相关的危险因素.另一方面,当检查影响维生素D水平的因素作为连续变量时,采用多元线性回归模型.
结果:所有参与者中维生素D缺乏的患病率为86.25%。男性维生素D缺乏的风险高于女性(β=0.383,P=0.026)。维生素D缺乏风险随年龄增长而降低(β=0.910,P<0.001)。此外,MHR值升高与维生素D缺乏风险增加相关(β=1.530,P=0.019).当将维生素D视为连续变量时,多元线性回归结果显示,年龄(β=0.342,P<0.001),TG(β=-1.327,P=0.010)是维生素D水平的独立影响因素,表明维生素D水平随着年龄的增长而增加。MHR和维生素D水平之间的反向关联显示出边际显著性趋势(β=-0.581,P=0.052)。
结论:在成都年轻医务人员中,维生素D与MHR呈负相关,中国。
OBJECTIVE: The primary objective of this study was to explore the association of vitamin D with the monocyte to HDL-C ratio (MHR) among medical staff in Chengdu, China.
METHODS: This cross-sectional study involved 538 medical staff, including 393 females and 145 males, and included data on gender, age, body mass index, and laboratory parameters (including complete blood count, vitamin D levels, lipid, etc.). According to serum 25 (OH)D < 20 ng/ml as vitamin D deficiency, subjects were divided into two groups based on serum 25 (OH)D levels: a vitamin D deficiency group with serum 25 (OH)D < 20 ng/ml and a vitamin D sufficiency group with serum 25 (OH)D ≥ 20 ng/ml. When considering vitamin D as a categorical variable, a multivariable logistic regression analysis was conducted to assess the risk factors associated with vitamin D deficiency. On the other hand, when examining the factors influencing vitamin D levels as a continuous variable, a multiple linear regression model was utilized.
RESULTS: The prevalence of vitamin D deficiency was 86.25% among all the participants. Males exhibited a higher risk of vitamin D deficiency compared to females (β=0.383, P = 0.026). Vitamin D deficiency risk decreased with age (β = 0.910, P < 0.001). Additionally, elevated values of MHR were associated with an increased risk of vitamin D deficiency (β = 1.530, P = 0.019). When treating vitamin D as a continuous variable, the results of multiple linear regression revealed that age (β = 0.342, P < 0.001), and TG (β=-1.327, P = 0.010) were independent influencing factors for vitamin D levels, indicating that vitamin D levels increase with age. A reverse association between MHR and vitamin D levels demonstrated a marginal trend toward significance (β=-0.581, P = 0.052).
CONCLUSIONS: Vitamin D is inversely associated with MHR among young medical staff in Chengdu, China.