关键词: 1,3-Dipolar cycloaddition Antidiabetic Molecular docking Rhodanine Spirooxindole pyrrolidine Structure-activity relationship (SAR) α-Amylase
Mesh : Alloxan Animals Diabetes Mellitus, Experimental / chemically induced drug therapy metabolism Dose-Response Relationship, Drug Glucose Tolerance Test Glycoside Hydrolase Inhibitors / chemical synthesis chemistry pharmacology Hypoglycemic Agents / chemical synthesis chemistry pharmacology Male Molecular Structure Oxindoles / chemical synthesis chemistry pharmacology Pyrrolidines / chemical synthesis chemistry pharmacology Rats Rats, Wistar Spiro Compounds / chemical synthesis chemistry pharmacology Structure-Activity Relationship alpha-Amylases / antagonists & inhibitors metabolism
来 源:
DOI:10.1016/j.bioorg.2020.104507
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