■糖尿病(DM)是一种长期疾病,其特征是由胰岛素抵抗引起的高血糖水平,这将导致其他疾病的并发症,例如血脂异常,这也会影响肝脏和肾脏的健康。蝴蝶豌豆花(ClitoreaternateaL.)具有酚类和类黄酮化合物,具有作为抗糖尿病药的草药的潜力。
■这项研究的目的是检查蝴蝶豌豆花提取物(BPE)作为抗糖尿病药的潜力,抗血脂异常,和保护肾脏。
■对链脲佐菌素-烟酰胺和高脂饮食-丙硫氧嘧啶诱导的SpragueDawley大鼠(RattusnorvegicusL.)进行体内试验,作为DM和血脂异常的模型,和BPE口服给药(200、400和800mg/kgBW)28天。谷胱甘肽过氧化物酶(GSH-Px),谷胱甘肽S-转移酶(GST),肿瘤坏死因子-α(TNF-α),核因子-κβ(NF-kB),碱性磷酸酶(ALP),肝白蛋白水平,血清尿素氮(BUN),血清肌酐,和血清尿酸(UA),用ELISA法和比色法进行测定。
■BPE800mg/kgBW的治疗增加了GSH-Px的水平,GST,白蛋白,和血清蛋白。BPE降低TNF-α,NF-kB,ALP。BPE也降低了BUN,血清CR,和血清UA。
■BPE具有用作治疗DM和血脂异常的药物替代品以及肝保护剂和肾脏保护剂的潜力。
UNASSIGNED: Diabetes mellitus (DM) is a long-term condition marked by high blood glucose levels caused by insulin resistance which will lead to complications of other diseases such as dyslipidemia, which also affects the health of the liver and kidneys. Butterfly pea flower (Clitorea ternatea L.) has phenolic and flavonoid compounds which have the potential as herbal medicines for antidiabetics.
UNASSIGNED: The purpose of this study is to examine the potential of butterfly pea flower extract (BPE) as an antidiabetic, anti-dyslipidemia, and renoprotection.
UNASSIGNED: In vivo test was performed on Sprague Dawley rats (Rattus norvegicus L.) induced by Streptozotocin-Nicotinamide and High Fat Diet-Propylthiouracil as models of DM and dyslipidemia, and BPE was administered orally (200, 400, and 800 mg/kg BW) for 28 days. glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), tumor necrosis factor-α (TNF-α), nuclear factor-kappa beta (NF-kB), alkaline phosphatase (ALP), liver albumin levels, serum blood urea nitrogen (BUN), serum creatinine, and serum uric acid (UA), were measured by ELISA and colorimetry methods.
UNASSIGNED: Treatment of BPE 800 mg/kg BW increased levels of GSH-Px, GST, albumin, and serum protein. BPE decreased TNF-α, NF-kB, and ALP. BPE also decreased BUN, serum CR, and serum UA.
UNASSIGNED: BPE has the potential to be used as a drug alternative for the treatment of DM and dyslipidemia as well as a hepatoprotective and renoprotective agent.