关键词： 3-PG, 3-phosphoglyceric acid ABC, ATP-binding cassette AIF, apoptosis-inducing factor AP-1, activator protein 1 ASCT2, alanine serine and cysteine transporter system 2 ATP, adenosine triphosphate BCR, B cell receptor BMDMs, bone marrow-derived macrophages CD45R, a receptor-type protein tyrosine phosphatase CTL, cytotoxic T lymphocytes DC, dendritic cells EAATs, excitatory amino acid transporters ER, endoplasmic reticulum ERRα, estrogen related receptor alpha FFA, free fatty acids G-6-P, glucose 6-phosphate GLUT, glucose transporters GSH, glutathione Glucose Glutamine HIF-1α, hypoxia-inducible factor 1-alpha HIV-1, human immunodeficiency virus type 1 Hk1, hexokinase-1 IFNβ, interferon beta IFNγ, interferon gamma IKK, IκB kinase IKKβ, IκB kinase beta subunit IL, interleukin LDHA, lactate dehydrogenase A LPS, lipopolysaccharide Lymphocytes Lyn, tyrosine-protein kinase MAPK, mitogen-activated protein kinase MCT, monocarboxylate transporters MS, multiple sclerosis Metal ion NADPH, nicotinamide adenine dinucleotide phosphate NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells NO, nitric oxide NOD2, nucleotide-binding oligomerization domain containing 2 PEG2, prostaglandin E2 PI-3K/AKT, phosphatidylinositol-3-OH kinase/serine–threonine kinase PPP, pentose phosphate pathway Pfk, phosphofructokinase RA, rheumatoid arthritis RLR, RIG-I-like receptor ROS, reactive oxygen species SLC, solute carrier SLE, systemic lupus erythematosus SNAT, sodium-coupled neutral amino acid transporters STAT, signal transducers and activators of transcription Solute carrier TAMs, tumor-associated macrophages TCA, tricarboxylic acid TCR, T cell receptor TLR, toll-like receptor TNF, tumor necrosis factor TRPM7, transient receptor potential cation channel subfamily M member 7 Teffs, effector T cells Th1/2/17, type 1/2/17 helper T cells Tregs, regulatory T cells VEGF, vascular endothelial growth factor ZIP, zrt/irt-like proteins iNOS, inducible nitric oxide synthase iTregs, induced regulatory T cells mTORC1, mammalian target of rapamycin complex 1 α-KG, α-ketoglutaric acid

来  源：   DOI：10.1016/j.apsb.2019.12.006   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
Solute carrier (SLC) transporters meditate many essential physiological functions, including nutrient uptake, ion influx/efflux, and waste disposal. In its protective role against tumors and infections, the mammalian immune system coordinates complex signals to support the proliferation, differentiation, and effector function of individual cell subsets. Recent research in this area has yielded surprising findings on the roles of solute carrier transporters, which were discovered to regulate lymphocyte signaling and control their differentiation, function, and fate by modulating diverse metabolic pathways and balanced levels of different metabolites. In this review, we present current information mainly on glucose transporters, amino-acid transporters, and metal ion transporters, which are critically important for mediating immune cell homeostasis in many different pathological conditions.
摘要：
溶质载体（SLC）转运蛋白冥想许多基本的生理功能，包括营养吸收，离子流入/流出，和废物处理。在对抗肿瘤和感染的保护作用中，哺乳动物免疫系统协调复杂的信号来支持增殖，分化,和单个细胞亚群的效应子功能。最近在这一领域的研究已经产生了令人惊讶的发现溶质载体转运蛋白的作用，它们被发现调节淋巴细胞信号并控制其分化，函数,和命运通过调节不同的代谢途径和不同代谢物的平衡水平。在这次审查中,我们目前的信息主要是关于葡萄糖转运蛋白，氨基酸转运蛋白，和金属离子输送器，这对于在许多不同的病理条件下介导免疫细胞稳态至关重要。
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