溶质载体转运蛋白 : 免疫细胞的代谢守门人。
关键词: 3-PG, 3-phosphoglyceric acid ABC, ATP-binding cassette AIF, apoptosis-inducing factor AP-1, activator protein 1 ASCT2, alanine serine and cysteine transporter system 2 ATP, adenosine triphosphate BCR, B cell receptor BMDMs, bone marrow-derived macrophages CD45R, a receptor-type protein tyrosine phosphatase CTL, cytotoxic T lymphocytes DC, dendritic cells EAATs, excitatory amino acid transporters ER, endoplasmic reticulum ERRα, estrogen related receptor alpha FFA, free fatty acids G-6-P, glucose 6-phosphate GLUT, glucose transporters GSH, glutathione Glucose Glutamine HIF-1α, hypoxia-inducible factor 1-alpha HIV-1, human immunodeficiency virus type 1 Hk1, hexokinase-1 IFNβ, interferon beta IFNγ, interferon gamma IKK, IκB kinase IKKβ, IκB kinase beta subunit IL, interleukin LDHA, lactate dehydrogenase A LPS, lipopolysaccharide Lymphocytes Lyn, tyrosine-protein kinase MAPK, mitogen-activated protein kinase MCT, monocarboxylate transporters MS, multiple sclerosis Metal ion NADPH, nicotinamide adenine dinucleotide phosphate NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells NO, nitric oxide NOD2, nucleotide-binding oligomerization domain containing 2 PEG2, prostaglandin E2 PI-3K/AKT, phosphatidylinositol-3-OH kinase/serine–threonine kinase PPP, pentose phosphate pathway Pfk, phosphofructokinase RA, rheumatoid arthritis RLR, RIG-I-like receptor ROS, reactive oxygen species SLC, solute carrier SLE, systemic lupus erythematosus SNAT, sodium-coupled neutral amino acid transporters STAT, signal transducers and activators of transcription Solute carrier TAMs, tumor-associated macrophages TCA, tricarboxylic acid TCR, T cell receptor TLR, toll-like receptor TNF, tumor necrosis factor TRPM7, transient receptor potential cation channel subfamily M member 7 Teffs, effector T cells Th1/2/17, type 1/2/17 helper T cells Tregs, regulatory T cells VEGF, vascular endothelial growth factor ZIP, zrt/irt-like proteins iNOS, inducible nitric oxide synthase iTregs, induced regulatory T cells mTORC1, mammalian target of rapamycin complex 1 α-KG, α-ketoglutaric acid
来 源:
DOI:10.1016/j.apsb.2019.12.006
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