关键词： head and neck cancer maxillary squamous cell carcinoma mortality oral cancer prediction model prognosis webcalculator

Mesh ： Carcinoma, Squamous Cell / mortality pathology surgery Cohort Studies Databases, Factual Disease-Free Survival Female Follow-Up Studies Humans Logistic Models Male Maxillary Neoplasms / mortality pathology surgery Multivariate Analysis Neoplasm Invasiveness / pathology Neoplasm Staging Oral Surgical Procedures / methods Predictive Value of Tests Probability Proportional Hazards Models Radiotherapy, Adjuvant Retrospective Studies Survival Analysis Time Factors Treatment Outcome

来  源：   DOI：10.1002/hed.25879   PDF(Sci-hub)

Abstract：
The aim of this article was to develop prediction models that calculate postoperative 2- and 5-year mortality probabilities of patients with squamous cell carcinoma of the maxilla (MSCC).
Data were collected from the medical records of patients who had been operated between 2000 and 2015 for MSCC. Potential clinical and histopathological predictors were identified. Confounding-(un)adjusted multivariate Cox and logistic regression models were computed with stepwise backward selection. Internal validation was performed to assess calibration and discriminatory ability.
Ninety-five patients with MSCC were included. Two-year follow-up was complete, and 85 patients had 5-year follow-up. Age, neck treatment, surgical margins, bone invasion, spindle growth, and vasoinvasive growth were associated with mortality. Models were adjusted for confounding with Charlson\'s comorbidities index. C-indexes were .841 and .770 respectively, and .838 and .749 after bootstrapping.
The MSCC-specific mortality probability can be calculated with new prediction models.
摘要：
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