■农药广泛用于农业活动。尽管已知使用杀虫剂会对人体造成伤害,其与甲状腺功能的关系尚不清楚。因此,本研究旨在探讨农药暴露与甲状腺功能的关系。
■使用的中国数据库包括60名拟除虫菊酯中毒患者和60名在2022年6月至2023年6月期间接受健康检查的参与者。NHANES数据库包括2007年至2012年注册的1,315名成年人。评估的农药及其代谢物包括2,4-二氯苯氧基乙酸(2,4-D),4-氟-3-苯氧基苯甲酸(4F3PB),对硝基苯酚(PN),3-苯氧基苯甲酸(3P),和反式-二氯乙烯基-二甲基环丙烷羧酸(TDDC)。通过纳入人群的血液测量甲状腺功能的评估指标。采用线性回归分析农药暴露与甲状腺功能指标的关系,贝叶斯核机回归(BKMR),限制三次样条(RCS),和加权分位数和(WQS)模型。
■中国数据显示,农药暴露与甲状腺功能指标FT4、TT4、TgAb呈负相关,和TPOAb(所有p<0.05)。NHANES数据的BKMR模型分析表明,多种农药的代谢混合物与FT4,TSH,Tg,与中国数据库的调查结果相似。此外,线性回归分析显示2,4-D和FT3(p=0.041)与4F3PB和FT4(p=0.003)正相关,而在4F3PB和Tg之间观察到负相关(p=0.001),4F3PB和TgAb(p=0.006),3P和TgAB(p=0.006),3P和TPOAb(p=0.03),PN和TSH(p=0.003),PN和TT4(p=0.031),以及TDDC和TPOAb(p<0.001)。RCS曲线表明,大多数农药代谢物与甲状腺功能指标呈负相关。最后,WQS模型分析显示,不同农药代谢物对甲状腺功能指标的影响存在显著差异。
■农药代谢产物与甲状腺功能指标呈显著负相关,不同农药代谢物对甲状腺功能指标的影响权重存在显著差异。需要更多的研究来进一步验证不同农药代谢物与甲状腺疾病之间的关联。
UNASSIGNED: Pesticides are widely used in agricultural activities. Although pesticide use is known to cause damage to the human body, its relationship with thyroid function remains unclear. Therefore, this study aimed to investigate the association between pesticide exposure and thyroid function.
UNASSIGNED: The Chinese database used included 60 patients with pyrethroid poisoning and 60 participants who underwent health checkups between June 2022 and June 2023. The NHANES database included 1,315 adults enrolled from 2007 to 2012. The assessed pesticide and their metabolites included 2,4-dichlorophenoxyacetic acid (2,4-D), 4-fluoro-3-phenoxybenzoic acid (4F3PB), para-nitrophenol (PN), 3-phenoxybenzoic acid (3P), and trans-dichlorovinyl-dimethylcyclopropane carboxylic acid (TDDC). The evaluated indicators of thyroid function were measured by the blood from the included population. The relationship between pesticide exposure and thyroid function indexes was investigated using linear regression, Bayesian kernel machine regression (BKMR), restricted cubic spline (RCS), and weighted quantile sum (WQS) models.
UNASSIGNED: The Chinese data showed that pesticide exposure was negatively correlated with the thyroid function indicators FT4, TT4, TgAb, and TPOAb (all p < 0.05). The BKMR model analysis of the NHANES data showed that the metabolic mixture of multiple pesticides was negatively associated with FT4, TSH, and Tg, similar to the Chinese database findings. Additionally, linear regression analysis demonstrated positive correlations between 2,4-D and FT3 (p = 0.041) and 4F3PB and FT4 (p = 0.003), whereas negative associations were observed between 4F3PB and Tg (p = 0.001), 4F3PB and TgAb (p = 0.006), 3P and TgAB (p = 0.006), 3P and TPOAb (p = 0.03), PN and TSH (p = 0.003), PN and TT4 (p = 0.031), and TDDC and TPOAb (p < 0.001). RCS curves highlighted that most pesticide metabolites were negatively correlated with thyroid function indicators. Finally, WQS model analysis revealed significant differences in the weights of different pesticide metabolites on the thyroid function indexes.
UNASSIGNED: There is a significant negative correlation between pesticide metabolites and thyroid function indicators, and the influence weights of different pesticide metabolites on thyroid function indicators are significantly different. More research is needed to further validate the association between different pesticide metabolites and thyroid disease.