PDF(Pubmed)
Abstract：
Magnetoencephalography (MEG) records weak magnetic fields outside the human head and thereby provides millisecond-accurate information about neuronal currents supporting human brain function. MEG and electroencephalography (EEG) are closely related complementary methods and should be interpreted together whenever possible. This manuscript covers the basic physical and physiological principles of MEG and discusses the main aspects of state-of-the-art MEG data analysis. We provide guidelines for best practices of patient preparation, stimulus presentation, MEG data collection and analysis, as well as for MEG interpretation in routine clinical examinations. In 2017, about 200 whole-scalp MEG devices were in operation worldwide, many of them located in clinical environments. Yet, the established clinical indications for MEG examinations remain few, mainly restricted to the diagnostics of epilepsy and to preoperative functional evaluation of neurosurgical patients. We are confident that the extensive ongoing basic MEG research indicates potential for the evaluation of neurological and psychiatric syndromes, developmental disorders, and the integrity of cortical brain networks after stroke. Basic and clinical research is, thus, paving way for new clinical applications to be identified by an increasing number of practitioners of MEG.
摘要：
脑磁图（MEG）记录了人类头部外部的弱磁场，从而提供了有关支持人脑功能的神经元电流的毫秒级准确信息。MEG和脑电图（EEG）是密切相关的互补方法，应尽可能一起解释。本手稿涵盖了MEG的基本物理和生理原理，并讨论了最先进的MEG数据分析的主要方面。我们为患者准备的最佳实践提供指南，刺激演示，MEG数据收集和分析，以及常规临床检查中的MEG解释。2017年，全球约有200个全头皮MEG设备在运行，其中许多位于临床环境中。然而，MEG检查的既定临床适应症仍然很少，主要限于癫痫的诊断和神经外科患者的术前功能评估。我们相信，广泛正在进行的基础MEG研究表明了评估神经和精神综合征的潜力，发育障碍,以及中风后大脑皮层网络的完整性。基础和临床研究,因此，为越来越多的MEG从业者确定新的临床应用铺平了道路。
