Charge-reversal nanoparticles: novel targeted drug delivery carriers.

电荷逆转纳米粒子 ： 新型靶向药物递送载体。

• 影响指数: 14.903
• 发表时间: Jul 2016
• 来源期刊: Acta Pharm Sin B
• DOI: 10.1016/j.apsb.2016.05.011
• PMID: 27471667
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Chen X,Liu L,Jiang C

关键词: Abs, integrin aVb3 mAbs; B-PDEAEA, poly[(2-acryloyl) ethyl (p-boronic acid benzyl) diethylammonium bromide]; BPS, bridged polysilsesquioxanexerogel; BSA, bovine serum albumin; CA4, combretastatin A4; CAPL, charge reversible pullulan-based; CHPNH2, cationic cholesteryl group–bearing pullulans; CMC, carboxymethyl cellulose; CPLAs, cationic polylactides; Cancer therapy; Charge-reversal nanoparticles; Cit, citraconic anhydride; Cya, cysteamine hydrochloride; DAP, 2,3-diamino-propionate; DCL, dimethyl maleamidic acid-ε-caprolactone; DDS, drug delivery system; DM, dimyristeroyl; DMA, 2,3-dimethylmaleic anhydride; DMPA, dimethylol propionic acid; DOX, doxorubicin; Drug delivery carriers; FITC, fluorescein isothiocyanate; GO, graphene oxide; GSH, glutathione; Glu, glutamic acid; HCC, hepatocellular carcinoma; HEP, 1,4-bis(2-hydroxyethyl) piperazine; HMP, p-hydroxylmethylenephenol; His, histidine; MG, microgels; MMPs, matrix metalloproteinases; MNP, magnetic nanoparticles; NPs, nanoparticles; Nanotechnology; PAEP, poly(allyl ethylene phosphate); PAH, poly(allylamine) hydrochloride; PBAE, poly(β-amino ester); PCL, poly(ε-caprolactone); PDADMAC, poly(diallyldimethylammonium chloride); PEG, polyethylene glycol; PEI, polyethylenimine; PEO, poly(ethylene oxide); PK, protein kinase; PLA, ploylactic acid; PLGA, poly(lactic-co-glycolic acid); PLL, poly(l-lysine); PMA, poly(methacrylic acid); PS, pH sensitive; PSS, poly(sodium 4-styrenesulfonate); PSSS, poly(styrene-co-4-styrene-sulfonate); PTX, paclitaxel; PU, polyurethane; PVPON, poly(N-vinylpyrrolidone); ROS, reactive oxygen species; SOD, superoxide dismutase; Stimuli responsive; TMA, 2-(mercaptoethyl) trimethylammonium chloride; TUNA, thioundecyl-tetraethyleneglycolester-o-nitrobenzy-lethyldimethyl ammonium bromide; pA-F, fluorescein-labeled polyanion

Abstract

Spurred by significant progress in materials chemistry and drug delivery, charge-reversal nanocarriers are being developed to deliver anticancer formulations in spatial-, temporal- and dosage-controlled approaches. Charge-reversal nanoparticles can release their drug payload in response to specific stimuli that alter the charge on their surface. They can elude clearance from the circulation and be activated by protonation, enzymatic cleavage, or a molecular conformational change. In this review, we discuss the physiological basis for, and recent advances in the design of charge-reversal nanoparticles that are able to control drug biodistribution in response to specific stimuli, endogenous factors (changes in pH, redox gradients, or enzyme concentration) or exogenous factors (light or thermos-stimulation).

摘要

在材料化学和药物输送方面取得重大进展的刺激下，电荷逆转纳米载体正在开发中，用于在空间上提供抗癌制剂，时间和剂量控制的方法。电荷逆转纳米颗粒可以响应于改变其表面电荷的特定刺激而释放其药物有效载荷。它们可以从循环中清除，并被质子化激活，酶促裂解，或分子构象变化.在这次审查中,我们讨论的生理基础，以及电荷逆转纳米粒子设计的最新进展，这些纳米粒子能够控制药物在特定刺激下的生物分布，内源性因素(pH变化，氧化还原梯度，或酶浓度)或外源因素(光或热刺激)。