伤口愈合,对组织修复至关重要的关键生物过程,刺激了全球市场超过150亿美元的伤口护理产品和120亿美元的疤痕治疗。慢性伤口导致伤口愈合延迟或受损。天然生物活性化合物,以最小的副作用而闻名,作为有效伤口愈合的有希望的候选人。作为回应,研究人员正在转向纳米技术,采用将这些试剂包封到药物递送载体中。药物递送系统将在靶向递送治疗剂以促进组织再生和解决诸如炎症等潜在问题方面发挥关键作用。感染,慢性伤口愈合中血管生成受损。药物递送载体提供了独特的优势,表现出相当大的表面积与体积之比以及改变的物理和化学性质。这些载体促进持续和控制释放,证明对伤口愈合的延长过程特别有利,通常包括各种各样的组件,整合天然和合成聚合物。此外,它们经常掺入生物活性分子。尽管他们的财产,包括溶解性差,快速降解,和有限的生物利用度,各种天然生物活性剂在临床应用中面临挑战。通过一项全球研究,强调利用纳米材料进行伤口愈合应用,这项研究概述涉及先进的药物递送技术,以增加使用生物活性分子的组织再生的有效性。药物递送的最新进展已准备好增强天然化合物在伤口愈合应用中的治疗功效。
Wound healing, a critical biological process vital for tissue restoration, has spurred a global market exceeding $15 billion for wound care products and $12 billion for scar treatment. Chronic wounds lead to delayed or impaired wound healing. Natural bioactive compounds, prized for minimal side effects, stand out as promising candidates for effective wound healing. In response, researchers are turning to nanotechnology, employing the encapsulation of these agents into drug delivery carriers. Drug delivery system will play a crucial role in enabling targeted delivery of therapeutic agents to promote tissue regeneration and address underlying issues such as inflammation, infection, and impaired angiogenesis in chronic wound healing. Drug delivery carriers offer distinct advantages, exhibiting a substantial ratio of surface area to volume and altered physical and chemical properties. These carriers facilitate sustained and controlled release, proving particularly advantageous for the extended process of wound healing, that typically comprise a diverse range of components, integrating both natural and synthetic polymers. Additionally, they often incorporate bioactive molecules. Despite their properties, including poor solubility, rapid degradation, and limited bioavailability, various natural bioactive agents face challenges in clinical applications. With a global research, emphasis on harnessing nanomaterial for wound healing application, this research overview engages advancing drug delivery technologies to augment the effectiveness of tissue regeneration using bioactive molecules. Recent progress in drug delivery has poised to enhance the therapeutic efficacy of natural compounds in wound healing applications.