关键词: Jordan folk medicine male sexual dysfunction medicinal plants natural products

Mesh : Animals Antioxidants / therapeutic use Aphrodisiacs / therapeutic use Erectile Dysfunction / drug therapy Evidence-Based Medicine Humans Jordan Male Medicine, Arabic Penile Erection / drug effects Phytotherapy Plant Extracts / therapeutic use Plants, Medicinal / chemistry Quality of Life Spermatogenesis / drug effects Testis / drug effects

来  源:   DOI:10.1111/and.12619   PDF(Sci-hub)

Abstract:
Male sexual dysfunction is a serious problem which has an impact on the quality of life. In Jordanian folk medicine, 56 plant species were reported to be used by males to improve sexual potency and as aphrodisiacs. The aim of this study was to search for scientific evidence justifying their folk use. Of the 15 studied plants, only five were found to enhance spermatogenesis. The other 10 were reported to decrease spermatogenesis at least by one study. The majority of the studied plants possessed a protective effect on testis in different in vivo models as well as antioxidant activities. The effect of these plants on steroidogenesis and the hypothalamic-gonadal axis was also reviewed. The effect of only five plants was studied on sexual behaviour enhancement and three of them were active. Three of the four studied plants enhanced erection. The mechanism of action of active constituents isolated from the studied plants was also investigated. In conclusion, many plants used in Jordanian folk medicine decreased or had no effect on spermatogenesis in animal models. These plants have antioxidant and/or adaptogenic effects, and this may result in a beneficial action on male reproductive system.
摘要:
男性性功能障碍是一个严重的问题,对生活质量有影响。在约旦民间医学中,据报道,雄性使用56种植物来提高性能力和用作壮阳药。这项研究的目的是寻找证明其民间使用合理的科学证据。在研究的15种植物中,只有五个被发现能促进精子发生。至少通过一项研究报道了其他10种减少精子发生。大多数研究的植物在不同的体内模型中对睾丸具有保护作用以及抗氧化活性。还回顾了这些植物对类固醇生成和下丘脑-性腺轴的影响。仅研究了五种植物对性行为增强的影响,其中三种具有活性。所研究的四种植物中的三种增强了勃起。还研究了从所研究的植物中分离出的活性成分的作用机理。总之,在动物模型中,约旦民间医学中使用的许多植物对精子发生减少或没有影响。这些植物具有抗氧化和/或适应性作用,这可能会对男性生殖系统产生有益的作用。
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