Prospective and retrospective evaluation of the Cepheid Xpert® Flu/RSV XC assay for rapid detection of influenza A, influenza B, and respiratory syncytial virus.

• 影响指数: 2.983
• 发表时间: Apr 2015
• 来源期刊: Diagn Microbiol Infect Dis
• DOI: 10.1016/j.diagmicrobio.2015.01.008
• PMID: 25662018
• 文章类型: Comparative Study
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Salez N,Nougairede A,Ninove L,Zandotti C,de Lamballerie X,Charrel RN

关键词: Diagnosis; Flu; Point-of-care; RT-PCR; Rapid Influenza Detection Test; Real-time PCR; Syncytial respiratory virus

Mesh: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Influenza A virus / isolation & purification; Influenza B virus / isolation & purification; Influenza, Human / diagnosis virology; Male; Middle Aged; Molecular Diagnostic Techniques / methods; Respiratory Syncytial Virus Infections / diagnosis virology; Respiratory Syncytial Viruses / isolation & purification; Sensitivity and Specificity; Time Factors; Virology / methods; Young Adult

Abstract

A total of 281 clinical specimens (nasal swabs and nasopharyngeal aspirates) were tested with the Xpert® Flu/RSV XC. The results were compared to those obtained with the real-time retro transcriptase-polymerase chain reaction assays routinely used in our laboratory. The Xpert® Flu/RSV XC showed sensitivity/specificity of 97.8%/100% and 97.9%/100% for flu and respiratory syncytial virus, respectively.