鱼类和哺乳动物脂质代谢基因转录调控网络的保守性。
关键词: 3-hydroxy-3-methyl-glutaryl-CoA reductase ABCA1 ACOX ARA ATP-binding cassette transporter 1 Atlantic salmon CYP7α1 DHA DMEM DNA complementary to RNA Dulbecco's modified eagle medium EDTA ELF-1α ELOVL EPA ER FA FADS FAS FBS FHM FO Fatty acid Gene expression HMG-CoAR LBD LC-PUFA LO LXR LXR response element LXRE Lipid ORF PBS PPAR PPAR response element PPRE PUFA Pyloric caeca RE RO RXR SCD SHK-1 SO SRE SREBP TF Transcription factor UAS VO aa acyl-CoA oxidase amino acid(s) arachidonic acid base pair(s) bp cDNA cholesterol 7alpha-hydroxylase docosahexaenoic acid eicosapentaenoic acid elongase of very long-chain fatty acids elongation factor 1 alpha endoplasmic reticulum ethylenediaminetetraacetic acid fathead minnow epithelial cells fatty acid fatty acid desaturase fatty acid synthase fetal bovine serum fish oil ligand binding domain linseed oil liver X receptor long-chain polyunsaturated fatty acids mRNA messenger RNA open reading frame peroxisome proliferator-activated receptors phosphate buffer saline polyunsaturated fatty acids qPCR quantitative RT-PCR rapeseed oil response element retinoid X receptor salmon head kidney cells serum response element soybean oil stearoyl CoA desaturase sterol regulatory element binding proteins transcription factor upstream activation sequence vegetable oil
Mesh : Animals Cholesterol / metabolism Dietary Fats / metabolism Fatty Acids / metabolism Female Fish Proteins / genetics metabolism Gene Regulatory Networks Lipid Metabolism / genetics Male Mammals / genetics Models, Biological Salmon / genetics metabolism Sterol Regulatory Element Binding Protein 1 / genetics metabolism Transcription Factors / genetics metabolism Transcription, Genetic
来 源: DOI:10.1016/j.gene.2013.10.040