目的:调查交感性眼炎(SO)患者的人口统计学和临床特征,并确定其在创伤和眼科手术后发生的危险因素。
方法:回顾性队列研究。
方法:美国眼科学会(学院)IRIS®注册(视力智能研究)的患者(n=1,523)或未被诊断为SO,2013年12月31日,2019.
方法:收集多个人口统计学和临床因素,计算描述性统计和患病率,和多元线性回归模型拟合数据。
方法:SO的患病率,人口统计学和临床特征,和β系数(β)估计的人口统计学和临床特征影响的时间到手术后(\'仅手术\'队列)或创伤(\'创伤队列\')。
结果:在65,348,409个不同的IRIS注册患者中,在2013年至2019年之间,有1,523(0.0023%)被诊断出患有SO,并且有记录的先前创伤或手术。其中,927(60.87%)为女性,1,336(87.72%)属于“仅限程序”队列,187人(12.28%)属于“创伤”队列。创伤后SO的患病率为0.0207%,术后为0.0124%。与手术相关的SO风险最高的是有“其他眼前节”病史的患者(0.122%),其次是青光眼(0.066%),而白内障手术的患病率最低(0.011%)。两个队列中SO的平均发病时间为527.44(±715.60)天,两组之间具有统计学上的显着差异(p<0.001)。平均而言,随着年龄的增长,从煽动事件到SO的发病时间缩短,每一年增加9.02天(95%CI:-11.96,-6.08)。
结论:因此创伤和眼科手术后可能比以前报道的更罕见,在这个大型眼科医疗记录数据库中测量。女性可能是SO的危险因素。年龄较大可能是发病较快的危险因素。这些发现可以指导临床决策和管理。
To investigate the demographic and clinical characteristics of patients with sympathetic ophthalmia (
SO) and define the risk factors for its incidence following trauma and ophthalmic procedures.
Retrospective cohort study.
Patients in the American Academy of Ophthalmology\'s (Academy) IRIS Registry (Intelligent Research in Sight) who were (n=1523) or were not diagnosed with
SO following a documented procedure or trauma between January 1, 2013, and December 31, 2019.
Multiple demographic and clinical factors were collected, descriptive statistics and prevalence were calculated, and multivariate linear regression models were fit to the data.
Prevalence of
SO, demographic and clinical characteristics, and beta coefficient (β) estimates of demographic and clinical characteristics impacting time to SO onset after procedure (Procedure Only cohort) or trauma (Trauma cohort).
Of 65,348,409 distinct IRIS Registry patients, 1523 (0.0023%) were diagnosed with SO between 2013 and 2019, and also had a documented preceding trauma or procedure. Of these, 927 (60.87%) were female, 1336 (87.72%) belonged to the Procedure Only cohort, and 187 (12.28%) belonged to the Trauma cohort. The prevalence of
SO after trauma was 0.0207%, whereas after procedures it was 0.0124%. The highest risk of procedure-related SO was seen in patients with history of \"other anterior segment\" (0.122%) followed by glaucoma (0.066%) procedures, whereas the lowest prevalence was noted with cataract surgeries (0.011%). The average time to onset of SO across both cohorts combined was 527.44 (±715.60) days, with statistically significant differences between the 2 cohorts (P < .001). On average, the time to onset from inciting event to SO was shorter with increasing age, by 9.02 (95% CI: -11.96, -6.08) days for every 1-year increase.
SO following trauma and ophthalmic procedure is potentially rarer than previously reported, as measured in this large ophthalmic medical record database. Female sex may be a risk factor for
SO. Older age may be a risk factor for quicker onset. These findings can guide clinical decision-making and management.