关键词： A Asn Asp BMI C C-reactive protein CAD CD36 Coronary artery disease DHPLC D′ ECG FA G GWAS Genetic association study HDL HapMap IVS3 IVS4 Ile International Haplotype Map Project LCFA LDL LOD LVMI Leu NCBI National Center for Biotechnology Information PCR Polymorphism Pro Risk factors ST Single Nucleotide Polymorphism database T Thr UTR adenosine asparagine aspartic acid body mass index coronary artery disease cytidine dbSNP denaturing high-performance liquid chromatography electrocardiography fatty acids genome-wide association study guanosine high density lipoprotein hsCRP intron number 3 intron number 4 isoleucine left ventricular mass index leucine logarithm of odds long chain fatty acids low density lipoprotein name of gene encodes CD36 protein polymerase chain reactions proline r(2) receptor, a fatty acid translocase reference snip number rs score of linkage disequilibrium the ST interval measured in electrocardiography threonine thymidine unstranslated region

Mesh ： Adult Aged CD36 Antigens / chemistry genetics Coronary Artery Disease / genetics metabolism pathology Exons Female Gene Frequency Genetic Association Studies Genotype Haplotypes Humans Infant Infant, Newborn Introns Lipid Metabolism / genetics Lipids / genetics Male Middle Aged Polymorphism, Single Nucleotide / genetics Risk Factors

来  源：   DOI：10.1016/j.gene.2013.06.061   PDF(Sci-hub)

Abstract：
CD36 is a fatty acid translocase in striated muscle cells and cardiomyocytes. Some study suggested that alterations in CD36 gene may be associated with coronary artery disease (CAD) risk. The aim of the current study was to compare the frequency of CD36 variants in region encoding lipid-binding domain in Caucasian patients with early-onset CAD, no-CAD adult controls and neonates. The study group comprised 100 patients with early onset CAD. The genetic control groups were 306 infants and 40 no-CAD adults aged over 70years. Exons 4, 5 and 6 including fragments of flanking introns were studied using the denaturing high-performance liquid chromatography technique and direct sequencing. Changes detected in analyzed fragment of CD36: IVS3-6 T/C (rs3173798), IVS4-10 G/A (rs3211892), C311T (Thr104Ile, not described so far) in exon 5, G550A (Asp184Asn, rs138897347), C572T (Pro191Leu, rs143150225), G573A (Pro191Pro, rs5956) and A591T (Thr197Thr, rs141680676) in exon 6. No significant differences in the CD36 genotype, allele and haplotype frequencies were found between the three groups. Only borderline differences (p=0.066) were found between early onset CAD patients and newborns in the frequencies of 591T allele (2.00% vs 0.50%) and CGCGCGT haplotype (2.00% vs 0.50%) with both IVS3-6C and 591T variant alleles. In conclusion, CD36 variants: rs3173798, rs3211892, rs138897347, rs5956, rs143150225 rs141680676 and C311T do not seem to be involved in the risk of early-onset CAD in Caucasian population.
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