Mesh ： Acute Kidney Injury / blood diagnosis surgery Aged Aged, 80 and over Biomarkers / blood Cardiopulmonary Bypass Case-Control Studies Chemokine CCL3 / blood Chemokine CCL4 / blood Chemokine CX3CL1 / blood Epidermal Growth Factor / blood Female Humans Immunoassay / instrumentation methods Interleukin-6 / blood Male Middle Aged Monitoring, Physiologic / methods Pilot Projects Prospective Studies Reproducibility of Results Sensitivity and Specificity Time Factors Treatment Outcome Vascular Cell Adhesion Molecule-1 / blood

来  源：   DOI：10.3109/1354750X.2010.485252   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
BACKGROUND: Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality.
OBJECTIVE: To evaluate the plasma profile of biomarkers potentially involved in AKI development following CPB.
METHODS: In a nested case-control study, plasma levels of 27 biomarkers in 11 AKI cases were compared with 25 controls.
RESULTS: Pre-CPB, plasma levels of epidermal growth factor and macrophage inflammatory protein-1beta, 2 h following CPB, soluble vascular cell adhesion molecule-1 (sVCAM-1), fractalkine and macrophage inflammatory protein-1alpha, and at later time points, sVCAM-1 and interleukin-6 were associated with AKI.
CONCLUSIONS: Biomarkers associated with AKI following CPB may merit further study.
摘要：
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