%0 Journal Article
%T Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control pilot study.
%A Liangos O
%A Addabbo F
%A Tighiouart H
%A Goligorsky M
%A Jaber BL
%J Biomarkers
%V 15
%N 5
%D Aug 2010
%M 20482449
%F 2.663
%R 10.3109/1354750X.2010.485252
%X <B>BACKGROUND: </B>Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality.<BR><B>OBJECTIVE: </B>To evaluate the plasma profile of biomarkers potentially involved in AKI development following CPB.<BR><B>METHODS: </B>In a nested case-control study, plasma levels of 27 biomarkers in 11 AKI cases were compared with 25 controls.<BR><B>RESULTS: </B>Pre-CPB, plasma levels of epidermal growth factor and macrophage inflammatory protein-1beta, 2 h following CPB, soluble vascular cell adhesion molecule-1 (sVCAM-1), fractalkine and macrophage inflammatory protein-1alpha, and at later time points, sVCAM-1 and interleukin-6 were associated with AKI.<BR><B>CONCLUSIONS: </B>Biomarkers associated with AKI following CPB may merit further study.