{Reference Type}: Journal Article
{Title}: Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control pilot study.
{Author}: Liangos O;Addabbo F;Tighiouart H;Goligorsky M;Jaber BL;
{Journal}: Biomarkers
{Volume}: 15
{Issue}: 5
{Year}: Aug 2010
{Factor}: 2.663
{DOI}: 10.3109/1354750X.2010.485252
{Abstract}: <B>BACKGROUND: </B>Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality.<BR><B>OBJECTIVE: </B>To evaluate the plasma profile of biomarkers potentially involved in AKI development following CPB.<BR><B>METHODS: </B>In a nested case-control study, plasma levels of 27 biomarkers in 11 AKI cases were compared with 25 controls.<BR><B>RESULTS: </B>Pre-CPB, plasma levels of epidermal growth factor and macrophage inflammatory protein-1beta, 2 h following CPB, soluble vascular cell adhesion molecule-1 (sVCAM-1), fractalkine and macrophage inflammatory protein-1alpha, and at later time points, sVCAM-1 and interleukin-6 were associated with AKI.<BR><B>CONCLUSIONS: </B>Biomarkers associated with AKI following CPB may merit further study.