背景:虽然酒精和危险行为之间的联系是众所周知的,酒精滥用和感染性传播感染(STIs)之间的明确相关性尚未确定.由4个问题组成的CAGE问卷-首字母缩写代表与酒精使用有关的态度和活动-通常在初级保健年度就诊时进行,以筛查患者是否存在酒精滥用。这项研究评估了CAGE评分与STI结果之间的关系,以确定CAGE问卷是否可以帮助确定每年访视时是否需要进行STI筛查。方法:将2015年至2022年在海湾南部卫生系统接受CAGE筛查的所有患者纳入分析。该研究的主要结果是CAGE评分阳性(评分≥2)与STI结果阳性之间的关系。主要分析中包括的性传播感染是人类免疫缺陷病毒(HIV),乙型肝炎,梅毒,衣原体,淋病,和滴虫病。CAGE评分阳性与丙型肝炎之间的相关性被视为次要结果。结果:在研究期间,共有40,022名患者接受了CAGE筛查,757(1.9%)在CAGE问卷中得分≥2。发现CAGE评分阳性与乙型肝炎之间存在显着关联(比值比[OR]=2.69,95%CI1.91,3.80;P<0.001),淋病(OR=5.43,95%CI1.80,16.39;P=0.003),和丙型肝炎(OR=2.10,95%CI1.57,2.80;P<0.001)。CAGE评分阳性与HIV之间没有发现关联,衣原体,或滴虫病。没有CAGE评分≥2的患者诊断为梅毒;因此,不可能进行梅毒分析.结论:根据本研究的结果,CAGE评分≥2的患者可能受益于乙型肝炎筛查,丙型肝炎,和淋病在他们的初级保健年度访问。早期的STI检测可以导致及时的治疗并防止进一步的传播和并发症。
Background: While the connection between alcohol and risky behavior is well known, a clear correlation between alcohol misuse and contracting sexually transmitted infections (STIs) has not been determined. The 4-question CAGE questionnaire-the acronym stands for attitudes and activities related to alcohol use-is often administered at primary care annual visits to screen patients for alcohol abuse. This study assessed the relationship between CAGE scores and STI results to determine if the CAGE questionnaire could help determine the need for STI screening at annual visits. Methods: All patients who received a CAGE screening from 2015 to 2022 at a Gulf South health system were included in the analysis. The primary outcome of the study was the relationship between a positive CAGE score (a score ≥2) and a positive STI result. STIs included in the primary analysis were human immunodeficiency virus (HIV), hepatitis B, syphilis, chlamydia,
gonorrhea, and trichomoniasis. The correlation between a positive CAGE score and hepatitis C was examined as a secondary outcome. Results: A total of 40,022 patients received a CAGE screening during the study period, and 757 (1.9%) scored ≥2 on the CAGE questionnaire. Significant associations were found between a positive CAGE score and hepatitis B (odds ratio [OR]=2.69, 95% CI 1.91, 3.80; P<0.001),
gonorrhea (OR=5.43, 95% CI 1.80, 16.39; P=0.003), and hepatitis C (OR=2.10, 95% CI 1.57, 2.80; P<0.001). No associations were found between a positive CAGE score and HIV, chlamydia, or trichomoniasis. No patients with a CAGE score ≥2 had a syphilis diagnosis; therefore, no syphilis analysis was possible. Conclusion: Based on the results of this study, patients with a CAGE score ≥2 may benefit from screening for hepatitis B, hepatitis C, and
gonorrhea at their primary care annual visit. Early STI detection could lead to prompt treatment and prevent further transmission and complications.