背景:本研究旨在探讨解脲支原体(UU)的感染和年龄分布,沙眼衣原体(CT),莆田生殖医学中心门诊患者中的淋病奈瑟菌(NG)和单纯疱疹病毒II型(HSVII),为福建省本地区各种生殖道疾病和不孕症的早期诊断和治疗提供临床依据。
方法:于2021年12月至2023年4月,采集莆田学院附属医院生殖医学中心门诊患者的宫颈分泌物和脱落细胞标本1736份。UU的感染,CT,实时荧光聚合酶链反应(PCR)检测NG和HSVII,以及不同性别患者的感染状况,分析了年龄和诊断。
结果:在1736例患者中,男性611人,女性1125人。男性患者UU感染率高于女性患者,HSVII感染率低于女性患者。性别之间的CT和NG感染率没有显着差异。随着年龄的增加,CT感染率逐渐降低。UU的区别,不同年龄组的NG和HSVII感染率无统计学意义。对于UU感染,男性不育患者的发病率最高,为37.72%(172/456)。同时,CT的差异,不同诊断组的NG和HSVII感染率无统计学意义。在男性和女性不育患者中,CT感染率在21-25岁年龄组中最高,分别为11.11%(2/18)和9.47%(9/95),分别。UU无统计学差异,CT,在与计划生育指导有关的不同年龄段的患者中以及在其他诊断结果的男女患者之间观察到NG和HSVII感染率。
结论:这项研究表明,UU是莆田不育男性中最常见的病原体,福建省。20岁以下人群CT感染率最高,感染显示出年轻人的倾向。因此,必须加强性健康知识的宣传,必须加强中青年性病的预防和治疗。此外,病原体感染在一定程度上与不孕有关,有利于临床诊断和治疗。
BACKGROUND: This study aims to explore the infection and age distribution of Ureaplasma urealyticum (UU), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Herpes simplex virus type II (HSV II) among the outpatients of Reproductive Medicine Center in Putian, Fujian Province to provide a clinical basis for the early diagnosis and treatment of various reproductive tract diseases and infertility in this region.
METHODS: A total of 1736 samples of secretions and exfoliated cervical cells were collected from the outpatients of the Reproductive Medicine Center of the Affiliated Hospital of Putian University from December 2021 to April 2023. The infections of UU, CT, NG and HSVII were detected by real-time fluorescence polymerase chain reaction (PCR), and the infection statuses of the patients with different genders, ages and diagnoses were analysed.
RESULTS: Among the 1736 patients, 611 were male and 1125 were female. The male patients had higher UU infection rate but lower HSV II infection rate than the female patients. No significant difference in CT and NG infection rates was observed between the genders. The CT infection rate gradually decreased with the increase in the age. The difference in UU, NG and HSV II infection rates among the different age groups was not statistically significant. For UU infection, the male infertile patients had the highest rate of 37.72% (172/456). Meanwhile, the differences in CT, NG and HSV II infection rates among the different diagnosis groups were not statistically significant. Among the male and female infertile patients, the CT infection rate was the highest in the 21-25 years of age group at 11.11% (2/18) and 9.47% (9/95), respectively. No statistically significant difference in UU, CT, NG and HSV II infection rates was observed among the different age groups of patients diagnosed in relation to the family planning guidance and between the male and female patients with other diagnoses results.
CONCLUSIONS: This study showed that UU was the most frequently identified pathogen in infertile men in Putian, Fujian Province. The CT infection rate was the highest in people under 20 years old, and the infection showed a tendency toward young individuals. Therefore, the publicity of sexual health knowledge must be strengthened, and the prevention and treatment of venereal diseases among young and middle-aged people must be improved. Moreover, the pathogen infection is related to infertility to a certain extent, which is conducive to clinical diagnosis and treatment.