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Abstract：
The antimicrobial resistance of Neisseria gonorrhoeae (NG) is an increasing public health concern, highlighted by the fact that gonococcus is considered as a \'high\'-priority pathogen by the WHO for research and development of new therapeutic options. According to the data of the European Centre for Disease Prevention and Control (ECDC) in 2022, the rate of NG infections is the highest recorded since European surveillance of sexually transmitted infections began in 2009. We report a brief description of a patient infected with two different isolates of drug-resistant N. gonorrhoeae. N. gonorrhoeae cultures were positive from oropharyngeal and urethral swabs and isolates had different antimicrobial susceptibility. We investigated the antimicrobial susceptibility of these isolates to six antimicrobials (ceftriaxone, cefixime, azithromycin, ciprofloxacin, tetracycline, and benzylpenicillin), and minimum inhibitory concentrations (MICs; mg/L) were determined using Etest on gonococcal isolates. Oropharyngeal isolate was resistant to azithromycin while urethral was resistant to penicillin, ciprofloxacin, and tetracycline. Two different and phylogenetically distinct sequence types of NG isolates were identified. Understanding the dynamics and drivers of resistance spread can provide an improved rationale for antibiotic management, and the level of NG resistance should be monitored closely.
摘要：
淋病奈瑟氏球菌（NG）的耐药性是一个日益增加的公共卫生问题，世卫组织将淋球菌视为“高度优先”病原体，以研究和开发新的治疗方案。根据欧洲疾病预防和控制中心（ECDC）2022年的数据，NG感染率是自2009年欧洲开始对性传播感染进行监测以来的最高记录。我们报告了感染两种不同的耐药淋病奈瑟菌分离株的患者的简要描述。淋病奈瑟菌的口咽部和尿道拭子培养阳性，分离株对抗菌药物的敏感性不同。我们调查了这些分离株对六种抗菌剂（头孢曲松，头孢克肟,阿奇霉素,环丙沙星,四环素,和苄青霉素），和最小抑制浓度（MIC；mg/L）使用Etest对淋球菌分离株进行测定。口咽分离株对阿奇霉素耐药，尿道对青霉素耐药，环丙沙星,还有四环素.鉴定了两种不同的和系统发育上不同的NG分离物序列类型。了解耐药性传播的动态和驱动因素可以为抗生素管理提供改进的理由。应密切监测NG电阻的水平。
