对用于治疗皮肤病的天然和可持续产品的需求日益增加。本系统评价旨在批判性地分析已发表的随机对照试验(RCT),并为姜黄素治疗各种皮肤病提供循证建议。2023年7月18日,使用PRISMA姜黄或姜黄素治疗皮肤病的指南,对已发表的文献进行了系统的搜索。根据牛津循证医学中心指南提出临床建议。我们确定了18项使用姜黄或姜黄素治疗牛皮癣的原始随机对照试验,放射性皮炎,口腔扁平苔藓,瘙痒,白癜风,头癣,面部红斑,和疤痕。牛皮癣,剖宫产瘢痕,瘙痒接受B级建议的放射性皮炎,口腔扁平苔藓,白癜风,头癣,并且面部红肿获得了建议C或D的等级。在所有分析的临床试验中,姜黄素被证明具有优异的安全性。需要进一步的研究来确定姜黄的最佳剂量和治疗参数。额外,较大,应进行RCT和非RCT,以进一步研究姜黄素作为皮肤病治疗选择的安全性和有效性。
There is increasing demand for natural and sustainable products for the treatment of dermatologic conditions. This systematic
review aims to critically analyze published randomized controlled trials (RCTs) and provide evidence-based recommendations on the therapeutic use of curcumin for a variety of dermatological diseases. A systematic search of published literature was performed on July 18, 2023 using PRISMA guidelines for turmeric or curcumin for the treatment of skin diseases. Clinical recommendations were made based on the Oxford Centre for Evidence-Based Medicine guidelines. We identified 18 original randomized controlled trials for use of turmeric or curcumin for psoriasis, radiation dermatitis, oral lichen planus, pruritis, vitiligo, tinea capitis, facial erythema, and scarring. Psoriasis, cesarean section scar, and pruritus received grade of recommendation B. Radiation dermatitis, oral lichen planus, vitiligo, tinea capitis, and facial redness received grade of recommendation C or D. Curcumin was demonstrated to have an excellent safety profile in all clinical trials analyzed. Further research is required to determine optimal dosing and treatment parameters of turmeric. Additional, larger, RCTs and non-RCTs should be conducted to further investigate the safety and efficacy of curcumin as a treatment option for dermatological diseases.