• 文章类型: Systematic Review
    背景:基于文本的数字媒体平台彻底改变了通信和信息共享,在心理健康和自杀预防领域提供宝贵的知识和理解。
    目的:本系统综述旨在确定如何将机器学习和数据分析应用于基于文本的数字媒体数据,以了解心理健康并帮助预防自杀。
    方法:对来自以下主要电子数据库的研究论文进行了系统综述:WebofScience,MEDLINE,Embase(通过MEDLINE),和PsycINFO(通过MEDLINE)。使用GoogleScholar进行手动搜索,以补充数据库搜索。
    结果:总体而言,包括19项研究,关于如何应用数据分析和机器学习技术的五个主要主题:(1)作为个人心理健康的预测指标,(2)了解个人心理健康和自杀行为是如何沟通的,(3)检测精神障碍和自杀风险,(4)确定寻求帮助的心理健康困难,(5)确定支持心理健康的干预措施的有效性。
    结论:我们的研究结果表明,数据分析和机器学习可用于获得有价值的见解,例如:与抑郁症有关的基于网络的对话在不同种族之间有所不同,青少年比成年人更频繁地进行关于自杀的网络对话,在基于网络的心理健康社区寻求支持的人在获得在线支持后感觉更好。数字工具和心理健康应用程序正在成功用于管理心理健康,特别是通过COVID-19的流行,在此期间,分析显示焦虑和抑郁增加,基于网络的社区在减少大流行期间的孤立方面发挥了作用。预测分析也被证明具有潜力,虚拟现实在提供预防性或治疗性护理方面显示出有希望的结果。未来的研究工作可以集中在优化算法上,以增强基于文本的数字媒体分析在心理健康和自杀预防方面的潜力。在解决抑郁症时,关键的一步是确定导致幸福的因素,并使用机器学习来预测这些幸福的来源。这可以扩展到理解各种活动如何在不同的社会经济群体中提高幸福感。利用从这些数据分析和机器学习中收集的见解,有机会制定数字干预措施,比如聊天机器人,旨在提供支持和解决心理健康挑战和自杀预防。
    BACKGROUND: Text-based digital media platforms have revolutionized communication and information sharing, providing valuable access to knowledge and understanding in the fields of mental health and suicide prevention.
    OBJECTIVE: This systematic review aimed to determine how machine learning and data analysis can be applied to text-based digital media data to understand mental health and aid suicide prevention.
    METHODS: A systematic review of research papers from the following major electronic databases was conducted: Web of Science, MEDLINE, Embase (via MEDLINE), and PsycINFO (via MEDLINE). The database search was supplemented by a hand search using Google Scholar.
    RESULTS: Overall, 19 studies were included, with five major themes as to how data analysis and machine learning techniques could be applied: (1) as predictors of personal mental health, (2) to understand how personal mental health and suicidal behavior are communicated, (3) to detect mental disorders and suicidal risk, (4) to identify help seeking for mental health difficulties, and (5) to determine the efficacy of interventions to support mental well-being.
    CONCLUSIONS: Our findings show that data analysis and machine learning can be used to gain valuable insights, such as the following: web-based conversations relating to depression vary among different ethnic groups, teenagers engage in a web-based conversation about suicide more often than adults, and people seeking support in web-based mental health communities feel better after receiving online support. Digital tools and mental health apps are being used successfully to manage mental health, particularly through the COVID-19 epidemic, during which analysis has revealed that there was increased anxiety and depression, and web-based communities played a part in reducing isolation during the pandemic. Predictive analytics were also shown to have potential, and virtual reality shows promising results in the delivery of preventive or curative care. Future research efforts could center on optimizing algorithms to enhance the potential of text-based digital media analysis in mental health and suicide prevention. In addressing depression, a crucial step involves identifying the factors that contribute to happiness and using machine learning to forecast these sources of happiness. This could extend to understanding how various activities result in improved happiness across different socioeconomic groups. Using insights gathered from such data analysis and machine learning, there is an opportunity to craft digital interventions, such as chatbots, designed to provide support and address mental health challenges and suicide prevention.
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  • 文章类型: Journal Article
    我们的目的是分析吸毒成瘾个体的犯罪行为与冲动性之间的关联,并调查冲动性是否介导了吸毒严重程度与法律问题之间的关系。
    这项横断面研究包括773名被诊断患有成瘾的男性(295名酒精使用者和478名可卡因/多物质使用者),同时接受成瘾治疗。BIS-11和ASI-6用于评估冲动,犯罪行为,和药物使用。
    在酒精使用者中,犯罪行为的患病率为41.7%(n=123),在裂纹/多物质使用者中,犯罪行为的患病率为64.9%(n=310)。在有犯罪史的个体中观察到较早使用不同物质和较高的冲动得分。调解分析表明,冲动是物质使用和犯罪行为之间的中介因素,提高法律问题的严重性。
    我们的研究结果可以帮助决定量身定制的治疗策略,不仅关注物质的使用,而且在预防社会问题上,犯罪,和冲动。
    UNASSIGNED: Our aim was to analyze the association between criminal behavior and impulsivity in individuals with drug addiction and investigate whether impulsiveness mediates the relationship between drug use severity and legal problems.
    UNASSIGNED: This cross-sectional study included 773 men diagnosed with addiction (295 alcohol users and 478 users of crack/polysubstance) while undergoing addiction treatment. The BIS-11 and ASI-6 were applied to assess impulsivity, criminal behavior, and drug use.
    UNASSIGNED: The prevalence of criminal behavior was 41.7% (n = 123) in alcohol users and 64.9% (n = 310) in users of crack/polysubstance. Earlier use of different substances and higher impulsivity scores were observed in individuals with criminal history. Mediation analyses revealed that impulsiveness acts as a mediator factor between substance use and criminal behavior, enhancing the severity of legal problems.
    UNASSIGNED: Our findings can help in deciding on tailored treatment strategies, focusing not only on substance use, but also on the prevention of social problems, criminality, and impulsivity.
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  • 文章类型: Journal Article
    美国是发达国家中孕产妇死亡率最高的国家。疾病控制和预防中心认为几乎所有这些死亡都是可以预防的,尤其是那些归因于精神健康状况的人。美国医疗保健和社会服务系统之间的协调可以帮助进一步描述与围产期自杀死亡率相关的情况和风险。
    检查与围产期自杀相关的背景和个体诱发情况和风险。
    这项横断面观察性研究使用了融合的混合方法设计,以探索导致孕产妇自杀和未确定意图死亡的因素(以下简称,未确定的死亡)在2003年1月1日至2021年12月31日的国家暴力死亡报告系统(NVDRS)数据中确定。分析包括10至50岁的死者,怀孕或产后死亡(统称,围产期组)和人口统计上匹配的女性死者,他们在死亡时未怀孕或最近怀孕(非围生期组)。在2022年12月至2023年12月之间进行了分析。
    死亡时的妊娠状态(围产期或非围产期)。
    主要结果包括死因裁判官中提到的与自杀和未确定死亡有关的促成情况,验尸官,或执法案件叙述。该研究使用匹配分析检查了组间的数量差异,并使用定性内容分析表征了突出自杀情况的关键主题。
    这项研究包括在NVDRS中确定的1150个围产期死者:456(39.6%)在死亡时怀孕,203人(17.7%)在死亡后42天内怀孕,491人(42.7%)在死前43至365天内怀孕,产生694名产后死者。非围产期对照组包括17655名10至50岁的女性死者。围产期死者的平均年龄(SD)为29.1(7.4)岁,非围产期死者的平均年龄为35.8(10.8)岁。与匹配的非围生儿相比,围产期死者在以下确定的促成情况中的几率更高:亲密伴侣问题(IPP)(优势比[OR],1.45[95%CI,1.23-1.72]),最近的论点(或,1.33[95%CI,1.09-1.61]),情绪低落(或,1.39[95%CI,1.19-1.63]),药物滥用或其他滥用(OR,1.21[95%CI,1.03-1.42]),身体健康问题(或,1.37[95%CI,1.09-1.72]),以及家庭成员或朋友的死亡(或,1.47[95%CI,1.06-2.02])。定性分析的结果强调了心理健康的重要性,并确定了128名患有产后抑郁症的死者(12.4%)。
    这项研究提供了有关孕产妇自杀的复杂因素的见解,它强调了进一步研究以了解围产期心理健康的长期后果的机会。这些发现还强调了有针对性的循证干预措施和针对精神卫生的有效政策的必要性,物质使用,和IPP,以防止产妇自杀和改善产妇健康结果。
    UNASSIGNED: The US has the highest maternal mortality rate among developed countries. The Centers for Disease Control and Prevention deems nearly all of these deaths preventable, especially those attributable to mental health conditions. Coordination between US health care and social service systems could help further characterize circumstances and risks associated with perinatal suicide mortality.
    UNASSIGNED: To examine contextual and individual precipitating circumstances and risks associated with perinatal suicide.
    UNASSIGNED: This cross-sectional observational study used a convergent mixed methods design to explore factors contributing to maternal suicides and deaths of undetermined intent (hereinafter, undetermined deaths) identified in National Violent Death Reporting System (NVDRS) data for January 1, 2003, to December 31, 2021. Analyses included decedents who were aged 10 to 50 years and pregnant or post partum at death (collectively, the perinatal group) and demographically matched female decedents who were not pregnant or recently pregnant (nonperinatal group) at death. Analyses were performed between December 2022 and December 2023.
    UNASSIGNED: Pregnancy status at death (perinatal or nonperinatal).
    UNASSIGNED: The main outcomes included contributing circumstances associated with suicides and undetermined deaths cited in coroner, medical examiner, or law enforcement case narratives. The study examined quantitative differences between groups using a matched analysis and characterized key themes of salient suicide circumstances using qualitative content analysis.
    UNASSIGNED: This study included 1150 perinatal decedents identified in the NVDRS: 456 (39.6%) were pregnant at death, 203 (17.7%) were pregnant within 42 days of death, and 491 (42.7%) were pregnant within 43 to 365 days before death, yielding 694 postpartum decedents. The nonperinatal comparison group included 17 655 female decedents aged 10 to 50 years. The mean (SD) age was 29.1 (7.4) years for perinatal decedents and 35.8 (10.8) years for nonperinatal decedents. Compared with matched nonperinatal decedents, perinatal decedents had higher odds of the following identified contributing circumstances: intimate partner problems (IPPs) (odds ratio [OR], 1.45 [95% CI, 1.23-1.72]), recent argument (OR, 1.33 [95% CI, 1.09-1.61]), depressed mood (OR, 1.39 [95% CI, 1.19-1.63]), substance abuse or other abuse (OR, 1.21 [95% CI, 1.03-1.42]), physical health problems (OR, 1.37 [95% CI, 1.09-1.72]), and death of a family member or friend (OR, 1.47 [95% CI, 1.06-2.02]). The findings of the qualitative analysis emphasized the importance of mental health and identified 128 decedents (12.4%) with postpartum depression.
    UNASSIGNED: This study provides insights into complex factors surrounding maternal suicide, and it highlights opportunities for further research to understand long-term consequences of perinatal mental health. These findings also underscore the need for targeted evidence-based interventions and effective policies targeting mental health, substance use, and IPPs to prevent maternal suicide and enhance maternal health outcomes.
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  • 文章类型: Journal Article
    目前强迫症的心理治疗方法,虽然有效,有复杂的结果和混合的疗效。先前的研究已经观察到强迫症患者的基线脑激活模式,阐明这种疾病的一些含义。观察基于证据的精神疗法对强迫症脑激活的影响(通过MRI)可以提供更全面的病理学概述。这项系统评价和荟萃分析评估了认知行为疗法(CBT)与暴露反应预防(ERP)对强迫症患者脑激活的影响。系统地搜索了学术数据库,评估的结局包括基线和治疗后大脑激活和症状严重程度的变化.患者(n=193)已确认OCD诊断,并接受了由训练有素的治疗师提供的ERP计划的原型CBT。CBT与ERP计划的参与者表现出症状严重程度的显着改善(Cohen'sd=-1.91)。总的来说,CBT与ERP导致额叶治疗后活化降低(Cohen'sd=0.40),顶叶(科恩的d=0.79),时间(科恩的d=1.02),和枕叶(科恩的d=0.76),和小脑(科恩的d=-0.78)。研究结果支持CBT与ERP改善OCD患者脑激活异常的能力。通过识别提高激活水平的区域,心理治疗计划可能受益于功能特异性功能的增加,这些功能特异性功能可以改善治疗结果.
    Current psychotherapeutic treatments for OCD, while effective, have complex outcomes with mixed efficacy. Previous research has observed baseline brain activation patterns in OCD patients, elucidating some of the implications of this disorder. Observing the effects of evidence-based psychotherapeutics for OCD on brain activation (through MRI) may provide a more comprehensive outline of pathology. This systematic review and meta-analysis evaluated the effects of cognitive behavioural therapy (CBT) with exposure-response prevention (ERP) on brain activation in OCD patients. Academic databases were systematically searched, and the outcomes evaluated included changes in brain activation and symptom severity between baseline and post-treatment. Patients (n = 193) had confirmed OCD diagnosis and underwent protocolized CBT with ERP programs delivered by trained therapists. Participants in the CBT with ERP programs demonstrated significant improvements in symptom severity (Cohen\'s d = - 1.91). In general, CBT with ERP resulted in decreased activation post-treatment in the frontal (Cohen\'s d = 0.40), parietal (Cohen\'s d = 0.79), temporal (Cohen\'s d = 1.02), and occipital lobe (Cohen\'s d = 0.76), and cerebellum (Cohen\'s d = - 0.78). The findings support CBT with ERP\'s ability to improve brain activation abnormalities in OCD patients. By identifying regions that improved activation levels, psychotherapy programs may benefit from the addition of function-specific features that could improve treatment outcomes.
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  • 文章类型: Journal Article
    商业性性剥削(CSE)是一个重大的公共卫生问题,不成比例地影响了少数民族化的女孩。尽管CSE与自杀企图有很强的关联,对有CSE历史的女孩自杀的相关性知之甚少。外部化障碍的发生率升高(即,注意缺陷/多动障碍[ADHD],破坏性行为障碍[DBD],行为障碍[CD])在CSE青年中观察到,特别是在国家分类的样本中。有CSE历史的青少年经常受到父母监禁的影响,这与自杀未遂的风险相关。我们在360名受CSE影响的不同种族的女孩(平均年龄=18.86)中,测试了外部化障碍和父母监禁与自杀企图次数的横断面同时关联。多动症,DBD,产妇监禁与自杀未遂次数呈正相关。研究结果暗示了这个边缘化群体中自杀未遂的临床/家族相关性,建议早期预防自杀的努力可以通过关注个人和家庭水平的因素来改善对这个问题的关注。
    Commercial sexual exploitation (CSE) is a significant public health concern disproportionately affecting ethnoracially minoritized girls. Despite strong associations of CSE with suicide attempts, little is known about correlates of suicide among girls with CSE histories. Elevated rates of externalizing disorders (i.e., attention-deficit/hyperactivity disorder [ADHD], disruptive behavior disorders [DBD], conduct disorder [CD]) were observed among CSE youth, particularly in ethnoracially minoritized samples. Youth with CSE histories are frequently affected by parental incarceration, which is correlated with risk for suicide attempts. We tested cross-sectional simultaneous associations of externalizing disorders and parental incarceration with number of suicide attempts among 360 ethnoracially diverse girls affected by CSE (Mean age = 18.86). ADHD, DBD, and maternal incarceration were positively associated with number of suicide attempts. Findings implicate clinical/familial correlates of suicide attempts in this marginalized group, suggesting early suicide prevention efforts may improve traction on this problem by focusing on individual and family level factors.
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  • 文章类型: Journal Article
    现有文献研究强迫症(OCD)患者抑郁症的相关性,其特征是结果不一致。本研究的目的是通过探索各种临床和人口统计学因素是否与OCD患者(M年龄=33.00;SD=12.47;74%女性)的大样本(N=243)中抑郁症的发生有关来复制和扩展文献。患有共病抑郁症状[患者健康问卷-9项(PHQ-9)≥10]的强迫症患者在所有强迫症症状亚型上得分均显着较高(p范围<.001-.048),具有更大的强迫性和强迫性严重性(ps<.001),完美主义得分较高(p<.001),与没有共病抑郁症状(PHQ-9<10)的个体相比,厌恶敏感性和倾向评分(ps<.001)更高。在这些变量中,痴迷严重程度(β=0.22,p=0.004),发现强迫症污染亚型(β=0.16,p=0.032)和完美主义(β=0.25,p<.001)与PHQ-9的抑郁症状有关。这项研究的发现有助于理解与强迫症患者抑郁症合并症相关的因素。
    The existing literature examining the correlates of depression in individuals with obsessive compulsive disorder (OCD) is characterized by inconsistent results. The aim of the current study was to replicate and extend the literature by exploring whether various clinical and demographic factors are related to the occurrence of depression in a large sample (N = 243) of individuals with OCD (M age = 33.00; SD = 12.47; 74% female). Individuals with OCD who had elevated comorbid depressive symptoms [Patient Health Questionnaire-9 item (PHQ-9) ≥10] scored significantly higher on all OCD symptom subtypes (p range < .001-.048), had greater obsessive and compulsive severity (ps < .001), scored higher on perfectionism (p < .001), and had higher disgust sensitivity and propensity scores (ps < .001) compared with individuals who did not have comorbid depressive symptoms (PHQ-9 < 10). Of these variables, obsession severity (β = 0.22, p = .004), OCD contamination subtype (β = 0.16, p = .032) and perfectionism (β = 0.25, p < .001) were found to be associated with depressive symptoms on the PHQ-9. The findings of this study contribute to the understanding of factors which are associated with depression comorbidity in individuals with OCD.
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  • 文章类型: Journal Article
    目的:舌下神经刺激(HGNS)治疗历来有严格的资格要求,包括体重指数(BMI)<32kg/m2。然而,最近食品和药物管理局的批准将适应症扩大到BMI<40kg/m2。体内脂肪分布有很大的可变性。这项研究试图确定颈围是否是比BMI更好的HGNS结果替代预测变量。
    方法:在三级护理中心对2017年3月至2021年10月由一名外科医生进行HGNS植入的成年人进行了回顾性图表审查。基线人口统计数据,包括颈围,收集了诊断性睡眠研究和植入后HGNS滴定研究.线性回归和Spearman相关系数(SCC)分析用于比较颈围(NC),预测颈围(PPNC)和BMI的百分比与有效电压下的呼吸暂停低通气指数(AHI-v)。
    结果:本研究包括43名中年人(61.1岁),以男性为主(76.7%),严重阻塞性睡眠呼吸暂停(AHI中位数35)和平均颈围15.3英寸。利用NC和PPNC,与AHI-v呈正相关(p=0.0033,SCC=.438,p=0.0029,SCC=.444).在控制BMI的同时,颈围增加1英寸与AHI-v增加35%相关(p=0.0411).
    结论:颈围较大与HGNS结局较差独立相关。需要进一步的研究来支持和证实这些发现,尤其是跨性别。
    OBJECTIVE: Hypoglossal nerve stimulation (HGNS) therapy has historically had strict eligibility requirements including a body mass index (BMI) < 32 kg/m2. However, recent Food and Drug Administration approval expanded indications to a BMI < 40 kg/m2. There is a wide variability in body fat distribution. This study sought to determine if neck circumference is a better surrogate predictive variable for HGNS outcomes than BMI.
    METHODS: A retrospective chart review was conducted at a tertiary care center on adults who underwent HGNS implantation by a single surgeon from March 2017 to October 2021. Baseline demographic data including neck circumference, diagnostic sleep studies and post-implantation HGNS titration studies were collected. Linear regression and Spearman\'s Correlation Coefficient (SCC) analysis were utilized to compare neck circumference (NC), percentage of predicted neck circumference (PPNC) and BMI with the apnea-hypopnea index at effective voltage (AHI-v).
    RESULTS: This study included 43 patients who were middle aged (61.1 years), predominantly male (76.7%), with severe obstructive sleep apnea (median AHI 35) and mean neck circumference of 15.3 inches. Utilizing the NC and PPNC, positive correlations with AHI-v were observed (p = 0.0033, SCC = .438, and p = 0.0029, SCC = .444). While controlling for BMI, a 1-inch increase in neck circumference was associated with a 35% increase in AHI-v (p = 0.0411).
    CONCLUSIONS: A larger neck circumference was independently associated with worse HGNS outcomes. Further research is needed to support and confirm these findings, particularly across sexes.
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  • 文章类型: Journal Article
    目的:关于OSA随时间进展或症状一致性的知识有限。我们的目标是检查症状亚型的变化并确定5年的预测因素。
    方法:分析了2,643名睡眠心脏健康研究参与者的完整基线和5年随访数据。对基线和随访确定的症状亚型的14种症状的潜在分类分析。在每个时间点将没有OSA(AHI<5)的个体作为已知类别并入。多项logistic回归评估了年龄的影响,性别,体重指数(BMI)和AHI对特定类别转换的影响。
    结果:样本包括1,408名女性(53.8%),平均(SD)年龄62.4(10.5)岁。我们在基线和随访时确定了四种OSA症状亚型:最小症状,睡眠不安,适度困倦,过度困倦。将近一半(44.2%)的样本过渡到不同的亚型;过渡到中度困倦是最常见的(所有过渡的77%)。五岁以上的年龄与从过度困倦过渡到中度困倦的几率增加50%相关[OR(95%CI:1.52(1.17,1.97)]。女性从中度困倦过渡到轻度症状的几率高1.97倍(95%CI:1.21,3.18)。BMI增加5个单位与从轻微症状过渡到过度困倦的2.39更多几率(95%CI:1.30,4.40)相关。AHI的变化不能显著预测任何转变。
    结论:OSA的症状可能随时间波动或保持稳定。OSA症状进展的知识可以支持临床医生的治疗决策。
    OBJECTIVE: There is limited knowledge regarding the progression or consistency of symptoms in OSA over time. Our objective was to examine the changes in symptom subtypes and identify predictors over a span of 5 years.
    METHODS: Data of 2,643 participants of the Sleep Heart Health Study with complete baseline and 5-year follow-up visits were analyzed. Latent Class Analysis on 14 symptoms at baseline and follow-up determined symptom subtypes. Individuals without OSA (AHI<5) were incorporated as a known class at each time point. Multinomial logistic regression assessed the effect of age, sex, body mass index (BMI) and AHI on specific class transitions.
    RESULTS: The sample consisted of 1,408 women (53.8%) and mean (SD) age 62.4 (10.5) years. We identified four OSA symptom subtypes at both baseline and follow-up visits: minimally symptomatic, disturbed sleep, moderately sleepy, and excessively sleepy. Nearly half (44.2%) of the sample transitioned to a different subtype; transitions to moderately sleepy were the most common (77% of all transitions). A five-year older age was associated with a 50% increase in odds to transit from excessively sleepy to moderately sleepy [OR (95% CI: 1.52 (1.17, 1.97)]. Women had 1.97 times higher odds (95% CI: 1.21, 3.18) to transition from moderately sleepy to minimal symptoms. A 5-unit increase in BMI was associated with 2.39 greater odds (95% CI: 1.30, 4.40) to transition from minimal symptoms to excessively sleepy. Changes in AHI did not significantly predict any transitions.
    CONCLUSIONS: The symptoms of OSA may fluctuate or remain stable over time. Knowledge of symptom progression in OSA may support clinicians with treatment decisions.
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  • 文章类型: Journal Article
    近年来,我们对精神分裂症阳性症状的理解有了重大进展,比如幻觉和妄想.通过在人类受试者和临床前动物模型中使用基于联想学习的方法,这一进展得到了显着帮助。这里,我们首先回顾了实验研究,重点是使用三种不同的条件现象对缺失刺激的异常处理:条件性幻觉,介导的条件,和跟踪调理。然后,我们回顾了研究使用习惯化减少物理存在但信息冗余刺激的局灶性处理能力的研究,潜在抑制,和阻塞。然后在Wagner(1981)的标准操作程序模型的框架内总结这些不同的研究路线的结果,一种联想学习模型,明确引用了当前和不存在的刺激的内部表示。在这个框架内,与阳性症状相关的中枢缺陷可以描述为未能抑制缺失刺激和存在但无关的刺激的局灶性处理。这可以解释在不同的实验设置中获得的广泛的结果。最后,我们简要讨论了海马体的作用及其与多巴胺能传递的相互作用在这种异常刺激表征和学习中的出现。总的来说,我们希望联想学习方法提供的理论框架和实证结果将继续促进和整合在心理和行为层面进行的精神分裂症分析,一方面,在另一个神经和分子水平上,通过充当它们之间的有用接口。(PsycInfo数据库记录(c)2024APA,保留所有权利)。
    In recent years, there have been significant advances in our understanding of the positive symptoms of schizophrenia, such as hallucinations and delusions. This progress has been significantly aided by the use of associative learning-based approaches in human subjects and preclinical animal models. Here, we first review experimental research focusing on the abnormal processing of absent stimuli using three different conditioning phenomena: conditioned hallucinations, mediated conditioning, and trace conditioning. We then review studies investigating the ability to reduce focal processing of physically present but informationally redundant stimuli using habituation, latent inhibition, and blocking. The results of these different lines of research are then summarized within the framework of Wagner\'s (1981) standard operating procedures model, an associative learning model with explicit reference to the internal representations of both present and absent stimuli. Within this framework, the central deficit associated with positive symptoms can be described as a failure to suppress the focal processing of both absent stimuli and present but irrelevant stimuli. This can explain the wide range of results obtained in different experimental settings. Finally, we briefly discuss the role of the hippocampus and its interaction with dopaminergic transmission in the emergence of such abnormal stimulus representations and learning. Overall, we hope that the theoretical framework and empirical findings offered by the associative learning approach will continue to facilitate and integrate analyses of schizophrenia conducted at the psychological and behavioral levels on the one hand, and at the neural and molecular levels on the other, by serving as a useful interface between them. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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  • 文章类型: Journal Article
    越来越多的文献表明,介导的学习技术对于在神经精神疾病的动物模型中进行现实测试具有特殊的用途。特别是,最近的工作表明,在进行介导学习时,在现实测试中,概括精神分裂症各种内表型的动物模型特别容易受到损害。多项研究表明,这些作用是多巴胺受体2依赖性的,并与异常的岛叶皮质(IC)活性相关。然而,直到现在,多巴胺与IC之间的联系尚未得到研究.这里,在野生型对照和表达显性阴性型精神分裂症破裂-1(DISC-1)基因的转基因小鼠中,我们利用一种新的交叉方法标记了特异性投射到岛叶皮质的中脑多巴胺细胞.使用这些技术,我们确定了从腹侧被盖区(VTA)投射到IC的细胞群。之后,我们进行了多项研究,以测试这种电路在从味觉检测到维持努力的行为中的必要性,最后,中介绩效。我们的结果表明,DISC-1遗传基因座的扰动导致VTA→IC电路中细胞数量的减少。行为上,VTA→IC电路不会影响味觉检测或获得蔗糖奖励的动机;但是,在介导的性能测试过程中,该电路的失活会差异抑制野生型和DISC-1转基因小鼠的巴甫洛夫方法行为。此外,在这些测试条件下,该电路的失活使野生型(但不是DISC-1)小鼠显示受损的现实测试。(PsycInfo数据库记录(c)2024APA,保留所有权利)。
    A growing body of literature indicates that mediated learning techniques have specific utility for tapping into reality testing in animal models of neuropsychiatric illness. In particular, recent work has shown that animal models that recapitulate various endophenotypes of schizophrenia are particularly vulnerable to impairments in reality testing when undergoing mediated learning. Multiple studies have indicated that these effects are dopamine receptor 2-dependent and correlated with aberrant insular cortex (IC) activity. However, until now, the connection between dopamine and the IC had not been investigated. Here, we utilized a novel intersectional approach to label mesencephalic dopamine cells that specifically project to the insular cortex in both wild-type controls and transgenic mice expressing the dominant-negative form of the Disrupted-in-Schizophrenia-1 (DISC-1) gene. Using these techniques, we identified a population of cells that project from the ventral tegmental area (VTA) to the IC. Afterward, we conducted multiple studies to test the necessity of this circuit in behaviors ranging from gustatory detection to the maintenance of effort and, finally, mediated performance. Our results indicate that perturbations of the DISC-1 genetic locus lead to a reduction in the number of cells in the VTA → IC circuit. Behaviorally, VTA → IC circuitry does not influence gustatory detection or motivation to acquire sucrose reward; however, inactivation of this circuit differentially suppresses Pavlovian approach behavior in wild-type and DISC-1 transgenic mice during mediated performance testing. Moreover, under these testing conditions, inactivation of this circuit predisposes wild-type (but not DISC-1) mice to display impaired reality testing. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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