背景:高危型人乳头瘤病毒(HPV)持续感染与宫颈癌密切相关。宫颈HPV的流行病学特征具有区域性差异。因此,要根据各地区的实际情况,制定最优惠的政策,预防和降低宫颈癌的患病率。这项回顾性横断面研究调查了患病率,基因亚型,温州地区体检女性HPV的时间变化趋势,为进一步预防和控制HPV提供决策依据。
方法:从温州地区体检的宫颈脱落细胞标本共31.131份,中国的一个沿海城市,从2015年到2020年收集。年龄分布采用卡方检验分析,时间变化趋势采用Mann-Kendall趋势检验进行分析。在此基础上,分析HPV亚型的分布特征.
结果:总患病率为9.55%,不同年龄组患病率为7.77%~14.16%。不同年份的患病率为8.84%~11.83%。患病率为双峰;在25岁的人群中最高,其次是该组>61岁。前5位的高危基因亚型分别为HPV52、HPV58、HPV53、HPV16和HPV39,而低风险亚型分别为HPV61、HPV81、HPV44、HPV43和HPV55。在所有阳性样本中,76.03%感染高危亚型。
结论:温州地区女性HPV患者多感染高危基因亚型。因此,应进一步加强HPV的体检和筛查,相应的疫苗接种政策应关注高危基因亚型。
背景:高危型人乳头瘤病毒(HPV)持续感染与宫颈癌的发生密切相关。宫颈HPV的流行特征具有区域性差异,因此,有必要根据每个地区的实际情况制定最优惠的政策,从而预防和降低宫颈癌的患病率。这项回顾性横断面研究调查了患病率,温州地区体检女性HPV基因亚型及时间变化趋势.为进一步防控HPV提供决策依据。
方法:从温州地区体检中获得的宫颈脱落细胞标本31,131份,收集了2015年至2020年的中国沿海城市。通过卡方检验分析年龄分布,并通过Mann-Kendall趋势检验分析时间变化趋势。在此基础上,分析HPV亚型分布特点。
结果:总患病率为9.55%,不同年龄组患病率为7.77%~14.16%。不同年份的患病率为8.84%~11.83%。患病率为双峰;在小于或等于25岁的组中最高,其次是大于61岁的组。前五名高危基因亚型分别为HPV52、HPV58、HPV53、HPV16和HPV39,而低危型分别为HPV61、HPV81、HPV44、HPV43和HPV55。在所有阳性样本中,76.03%感染高危亚型。
BACKGROUND: Persistent infection with high-risk human papillomavirus (HPV) is closely related to cervical cancer. The epidemiologic characteristics of cervical HPV have regional differences. Therefore, it is necessary to develop the most favorable policies according to the actual situation of each region to prevent and reduce the prevalence of cervical cancer. This retrospective cross-sectional study investigated the prevalence, gene subtypes, and temporal trends of HPV in women undergoing physical examination in Wenzhou, to provide a decision-making basis for further prevention and control of HPV.
METHODS: A total of 31 131 cervical exfoliated cell specimens obtained from physical examinations in Wenzhou, a coastal city of
China, from 2015 to 2020 were collected. The age distribution was analyzed using the chi-squared test, and the time change trend was analyzed using the Mann-Kendall trend test. On this basis, the distribution characteristics of the HPV subtypes were analyzed.
RESULTS: The total prevalence rate was 9.55%, and the prevalence rate in different age groups ranged from 7.77% to 14.16%. The prevalence rate in different years was 8.84%-11.83%. The prevalence rate was bimodal; it was highest in the group 25 years old, followed by the group >61 years old. The top five high-risk gene subtypes were HPV52, HPV58, HPV53, HPV16, and HPV39, whereas the low-risk subtypes were HPV61, HPV81, HPV44, HPV43, and HPV55. Of all the positive samples, 76.03% were infected with a high-risk subtype.
CONCLUSIONS: Most female HPV patients in Wenzhou are infected with high-risk gene subtypes. Therefore, physical examination and screening for HPV should be further strengthened, and the corresponding vaccination policy should focus on high-risk gene subtypes.
BACKGROUND: Persistent infection with high-risk human papillomavirus (HPV) is closely related to the occurrence of cervical cancer. The epidemic characteristics of cervical HPV have regional differences, Therefore, it is necessary to formulate the most favorable policies according to the actual situation of each region, so as to prevent and reduce the prevalence of cervical cancer. This retrospective cross-sectional study investigated the prevalence, gene subtypes and temporal trends of HPV in women undergoing physical examination in Wenzhou. To provide decision-making basis for further prevention and control of HPV.
METHODS: A total of 31,131 cervical exfoliated cell specimens obtained from physical examinations in Wenzhou, a coastal city of
China from 2015 to 2020, were collected. The age distribution was analyzed by the chi-squared test, and the time change trend was analyzed by the Mann–Kendall trend test. On this basis, the distribution characteristics of HPV subtypes were analyzed.
RESULTS: The total prevalence rate was 9.55%, and the prevalence rate in different age groups ranged from 7.77% to 14.16%. The prevalence rate in different years was 8.84%-11.83%. The prevalence rate was bimodal; it was highest in the group less than or equal to 25 years old, followed by the group greater than 61 years old. The top five high-risk gene subtypes were HPV52, HPV58, HPV53, HPV16 and HPV39, while for low-risk were HPV61, HPV81, HPV44, HPV43 and HPV55, respectively. Of all the positive samples, 76.03% were infected with a high-risk subtype.