PDF(Pubmed)
Abstract：
Asprosin, an adipokine, was recently discovered in 2016. Here, the correlation between asprosin and metabolic-associated fatty liver disease (MAFLD) was examined by quantitatively assessing hepatic steatosis using transient elastography and controlled attenuation parameter (CAP). According to body mass index (BMI), 1276 adult participants were enrolled and categorized into three groups: normal, overweight, and obese. The study collected and evaluated serum asprosin levels, general biochemical indices, liver stiffness measure, and CAP via statistical analysis. In both overweight and obese groups, serum asprosin and CAP were greater than in the normal group (p < 0.01). Each group showed a positive correlation of CAP with asprosin (p < 0.01). The normal group demonstrated a significant and independent positive relationship of CAP with BMI, low-density lipoprotein cholesterol (LDL-C), asprosin, waist circumference (WC), and triglycerides (TG; p < 0.05). CAP showed an independent positive association (p < 0.05) with BMI, WC, asprosin, fasting blood glucose (FBG), and TG in the overweight group, and with high-density lipoprotein cholesterol (HDL-C) showed an independent negative link (p < 0.01). CAP showed an independent positive relationship (p < 0.05) with BMI, WC, asprosin, TG, LDL-C, FBG, glycated hemoglobin A1c (HbA1c), and alanine transferase in the obese group. CAP also showed an independent positive link (p < 0.01) with BMI, WC, asprosin, TG, LDL-C, and FBG in all participants while independently and negatively correlated (p < 0.01) with HDL-C. Since asprosin and MAFLD are closely related and asprosin is an independent CAP effector, it may offer a novel treatment option for metabolic diseases and MAFLD.
摘要：
Asprosin,脂肪因子,最近在2016年被发现。这里,通过使用瞬时弹性成像和受控衰减参数(CAP)定量评估肝性脂肪变性,研究了Asprosin与代谢相关脂肪肝(MAFLD)之间的相关性.根据体重指数（BMI），1276名成年参与者被纳入研究，分为三组：正常，超重,和肥胖。该研究收集并评估了血清中的反前列腺素水平，一般生化指标，肝脏硬度测量，和CAP通过统计分析。在超重和肥胖人群中，血清Asprosin和CAP高于正常组（p<0.01）。各组CAP与天门冬氨酸呈正相关(p<0.01)。正常组CAP与BMI呈显著且独立的正相关,低密度脂蛋白胆固醇（LDL-C），asprosin,腰围（WC），和甘油三酯(TG;p<0.05)。CAP与BMI呈独立正相关(p<0.05),WC,asprosin,空腹血糖（FBG），超重组的TG，并与高密度脂蛋白胆固醇(HDL-C)表现出独立的负联系(p<0.01)。CAP与BMI呈独立的正相关(p<0.05),WC,asprosin,TG,LDL-C,FBG,糖化血红蛋白A1c（HbA1c），肥胖组的丙氨酸转移酶。CAP还显示出与BMI的独立正联系（p<0.01），WC,asprosin,TG,LDL-C,所有参与者的FBG与HDL-C呈独立负相关（p<0.01）。由于Asprosin和MAFLD密切相关，并且Asprosin是一种独立的CAP效应物，它可能为代谢性疾病和MAFLD提供新的治疗选择。
