PDF(Pubmed)
Abstract：
BACKGROUND: Little has been done to establish biobanks for studying the environment and lifestyle risk factors for diseases among the school-age children. The Minhang Pediatric Biobank (MPB) cohort study aims to identify factors associated with health and diseases of school-aged children living in the urban or suburban area of Shanghai.
METHODS: This population-based cohort study was started in all sub-districts/towns of Minhang district of Shanghai in 2014. First-grade students in elementary school were enrolled during the time of their routine physical examinations, with self-administered questionnaires completed by their primary caregivers. Additional information was extracted from multiple health information systems. Urine and saliva samples were collected during the baseline survey and follow-up visits.
RESULTS: At the end of 2014 academic year, a total number of 8412 children and their parents were recruited, including 4339 boys and 4073 girls. All the participants completed the baseline survey and physical examination, and 7128 urine and 2767 saliva samples were collected. The five most prevalent childhood diseases in this population were dental caries, bronchitis, pneumonia, asthma and overweight/obese.
CONCLUSIONS: The MPB cohort has been successfully established, serving as a useful platform for future research relating to the genetic, environmental and lifestyle risk factors for childhood diseases.
METHODS: This population-based cohort study was started in all sub-districts/towns of Minhang district of Shanghai in 2014. First-grade students in elementary school were enrolled during the time of their routine physical examinations, with self-administered questionnaires completed by their primary caregivers. Additional information was extracted from multiple health information systems. Urine and saliva samples were collected during the baseline survey and follow-up visits.
RESULTS: At the end of 2014 academic year, a total number of 8412 children and their parents were recruited, including 4339 boys and 4073 girls. All the participants completed the baseline survey and physical examination, and 7128 urine and 2767 saliva samples were collected. The five most prevalent childhood diseases in this population were dental caries, bronchitis, pneumonia, asthma and overweight/obese.
CONCLUSIONS: The MPB cohort has been successfully established, serving as a useful platform for future research relating to the genetic, environmental and lifestyle risk factors for childhood diseases.
摘要：
背景：建立用于研究学龄儿童疾病的环境和生活方式风险因素的生物库的工作很少。闵行儿科生物库（MPB）队列研究旨在确定与生活在上海市区或郊区的学龄儿童的健康和疾病相关的因素。
方法：这项基于人群的队列研究于2014年在上海市闵行区所有街道/乡镇开展。小学一年级学生在例行体检时入学,由他们的主要照顾者填写的自我管理问卷。从多个健康信息系统中提取了其他信息。在基线调查和随访期间收集尿液和唾液样本。
结果：在2014学年结束时，招募了8412名儿童及其父母，其中包括4339名男孩和4073名女孩。所有参与者都完成了基线调查和体检，收集了7128份尿液和2767份唾液样本。这个人群中最常见的五种儿童疾病是龋齿，支气管炎,肺炎,哮喘和超重/肥胖。
结论：MPB队列已成功建立，作为未来与遗传有关的研究的有用平台，儿童疾病的环境和生活方式危险因素。
方法：这项基于人群的队列研究于2014年在上海市闵行区所有街道/乡镇开展。小学一年级学生在例行体检时入学,由他们的主要照顾者填写的自我管理问卷。从多个健康信息系统中提取了其他信息。在基线调查和随访期间收集尿液和唾液样本。
结果：在2014学年结束时，招募了8412名儿童及其父母，其中包括4339名男孩和4073名女孩。所有参与者都完成了基线调查和体检，收集了7128份尿液和2767份唾液样本。这个人群中最常见的五种儿童疾病是龋齿，支气管炎,肺炎,哮喘和超重/肥胖。
结论：MPB队列已成功建立，作为未来与遗传有关的研究的有用平台，儿童疾病的环境和生活方式危险因素。
