目的:戊型肝炎病毒(HEV)是世界上急性病毒性肝炎的最常见原因。戊型肝炎感染通常由粪便口腔途径和污染的水传播。本研究旨在探讨木尔坦地区孕妇戊型肝炎感染的患病率和危险因素。巴基斯坦。
方法:本研究共纳入500名患者,其中,105名戊型肝炎感染孕妇符合抗HEV抗体标准。没有明显并发症和没有戊型肝炎感染的孕妇被排除在本研究之外。肝脏轮廓,全血细胞计数,凝血标志物,和标准方案也评估了胎儿母体出血。
结果:我们的结果显示105例患者(66.66%,CI95%)患有HEV感染,平均年龄25±5岁。74例患者血清胆红素水平升高(70.47%),天门冬氨酸转氨酶升高>200IU/L71例(67.61%),65例患者的丙氨酸转氨酶高于100IU/L(245IU/L),45例(42.85%)患者血小板计数偏低。此外,胎儿窘迫病例为9例(10.84%),产妇窘迫病例约为11例(13.25%)。胎儿死亡病例为39例(37.14%),由于肝逗号,孕产妇死亡病例约为22例(20.95%),血管内凝血,和肝功能衰竭.
结论:结论是,妊娠期间戊型肝炎的患病率与不卫生的高风险因素有关,输血,和不遵守通用感染控制技术。HEV感染加剧了孕产妇死亡和胎儿后果。
OBJECTIVE: Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis in the world. Hepatitis E infection is commonly widespread by the fecal oral routes and contaminated water. This study was designed to explore the prevalence and risk factors of hepatitis E infection in pregnant women of the Multan district, Pakistan.
METHODS: The study comprised of a total of 500 enrolled patients, among which, 105 pregnant females with hepatitis E infection fulfilled the criteria for anti-HEV antibodies. Pregnant women without significant complications and without hepatitis E infection were excluded from this study. Hepatic profile, complete blood count, coagulation markers, and standard protocol were also assessed for fetal maternal hemorrhage.
RESULTS: Our results showed that 105 patients (66.66%, CI 95%) had HEV infection with mean age 25±5 years. Serum bilirubin levels were increased in 74 patients (70.47%), aspartate transaminase was elevated > 200 IU/L in 71 patients (67.61%), alanine transaminase was above the 100 IU/L in 65 patients (245 IU/L), and low platelet counts were found in 45 patients (42.85%). Moreover, fetal distress cases were 9 (10.84%) and maternal distress cases were about 11 (13.25%). Fetal mortality cases were 39 (37.14%), and maternal mortality cases were about 22 (20.95%) due to hepatic comma, intravascular coagulation, and hepatic failure.
CONCLUSIONS: It was concluded that the prevalence of Hepatitis E during pregnancy is associated with high risk factors of unhygienic practices, blood transfusion, and noncompliance with universal infection control techniques. Maternal fatalities and fetal consequences were exacerbated by HEV infection.