背景:2019年冠状病毒病(COVID-19)大流行,由SARS-CoV-2病毒引起,已经对呼吸系统产生了深远的影响。越来越多的证据表明,COVID-19可以影响各种器官系统,包括眼睛。这项研究旨在阐明患病率,特点,以及诊断为COVID-19的患者的眼科表现的临床意义。
方法:这项回顾性研究分析了2020年3月1日至2020年12月31日在大型三级学术医疗中心住院的COVID-19成年患者的电子病历数据。眼科表现,包括结膜炎,干眼症症状,眼痛,顿唇,眼睛发红,和视觉障碍,被识别并检查其患病率,发病,持续时间,以及与COVID-19严重程度和全身症状的关系。
结果:在纳入研究的342名患者中,106例(31.0%)在COVID-19疾病期间经历了至少一种眼科表现。结膜炎是62例患者中最常见的表现(18.1%),其次是干眼症状38例(11.1%),27例患者的眼部疼痛/不适(7.9%),19例患者(5.6%),14例患者出现眼部红肿(4.1%),和视力障碍9例(2.6%)。眼科表现与严重的COVID-19疾病显着相关(42.9%与26.7%,p=0.003)和发热等全身症状的存在,咳嗽,和呼吸困难。中位发病时间为6天,中位持续时间为10天。
结论:COVID-19患者普遍存在眼部表现,特别是那些有严重疾病和全身症状的人。该研究强调了识别和管理受影响个体眼部症状的重要性,并强调了COVID-19的多面性,需要跨学科合作才能实现全面的患者护理。
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic, caused by the SARS-CoV-2 virus, has had far-reaching implications beyond the respiratory system. Mounting evidence suggests that COVID-19 can impact various organ systems, including the eyes. This study aimed to elucidate the prevalence, characteristics, and clinical implications of ophthalmic manifestations in patients diagnosed with COVID-19.
METHODS: This retrospective study analyzed data from electronic medical records of adult patients hospitalized with COVID-19 between March 1, 2020, and December 31, 2020, at a large tertiary academic medical center. Ophthalmic manifestations, including conjunctivitis, dry eye symptoms, ocular pain, epiphora, ocular redness, and visual disturbances, were identified and examined for their prevalence, onset, duration, and associations with COVID-19 severity and systemic symptoms.
RESULTS: Among 342 patients included in the study, 106 (31.0%) experienced at least one ophthalmic manifestation during their COVID-19 illness. Conjunctivitis was the most common manifestation in 62 patients (18.1%), followed by dry eye symptoms in 38 patients (11.1%), ocular pain/discomfort in 27 patients (7.9%), epiphora in 19 patients (5.6%), ocular redness in 14 patients (4.1%), and visual disturbances in nine patients (2.6%). Ophthalmic manifestations were significantly associated with severe COVID-19 illness (42.9% vs. 26.7%, p = 0.003) and the presence of systemic symptoms such as fever, cough, and dyspnea. The median time of onset was six days, and the median duration was 10 days.
CONCLUSIONS: Ophthalmic manifestations are prevalent in COVID-19 patients, particularly in those with severe illness and systemic symptoms. The study highlights the importance of recognizing and managing ocular symptoms in affected individuals and underscores the multifaceted nature of COVID-19, necessitating interdisciplinary collaboration for comprehensive patient care.