■要对疗效进行比较分析,安全,以及热消融和手术干预对甲状腺乳头状癌(PTC)患者生活质量的影响。
■进行了一项前瞻性研究,接受射频消融(RFA)的PTC≤5mm患者,激光烧蚀(LA),或者手术,用于分析疗效和安全性结果。在治疗前和治疗后3、6和12个月对所有患者进行甲状腺癌特异性生活质量问卷。
■总共162名符合条件的患者被纳入研究。RFA和LA组未观察到主要并发症,手术组报告了5例,尽管没有观察到统计学上的显着差异。轻微的并发症被记录在两个,三,和14名RFA患者,洛杉矶,和手术组,分别,没有明显的差异。热消融组的手术时间和住院时间明显较短。在最后的后续行动中,在接受RFA治疗的病例中,有71.4%的结节完全消失,在接受LA治疗的病例中,有71.0%的结节完全消失。组间没有显著差异。RFA和LA对生活质量的影响相似,与手术相比,热消融技术显示出更好的功能结果。在所有团体中,不良反应在治疗后3个月时最为明显,但热消融组逐渐恢复至基线水平,与手术组相比。
■对于PTC≤5mm,RFA和LA均表现出相似的癌症控制结局和优于手术的生活质量,同时尽量减少并发症。这些发现强调了RFA和LA作为小型PTC的潜在标准治疗的前景。有待在未来的研究中进一步证实。
UNASSIGNED: To conduct a comparative analysis of the efficacy, safety, and impact on quality of life outcomes between thermal ablation and surgical interventions in patients diagnosed with papillary thyroid carcinoma (PTC).
UNASSIGNED: A prospective study was undertaken, enrolling patients with PTC ≤5mm who underwent radiofrequency ablation (RFA), laser ablation (LA), or surgery, for analysis of efficacy and safety outcomes. The Thyroid Cancer-Specific Quality of Life questionnaire was administered to all patients before treatment and at 3, 6, and 12 months post-treatment.
UNASSIGNED: A total of 162 eligible patients were included in the study. Major complications were not observed in the RFA and LA groups, while five cases were reported in the surgery group, although no statistically significant differences were observed. Minor complications were documented in two, three, and 14 patients in the RFA, LA, and surgery groups, respectively, with no significant variances noted. Surgical duration and hospitalization time were notably shorter in the thermal ablation groups. At the final follow-up, complete disappearance of nodules was seen in 71.4% of cases treated with RFA and 71.0% of cases managed with LA, with no significant disparities between the groups. Both RFA and LA exhibited similar effects on quality of life, with thermal ablation techniques showing better functional outcomes in comparison to surgery. Across all groups, adverse effects were most pronounced at the 3-month post-treatment mark but gradually reverted to baseline levels in the thermal ablation group, contrasting with the surgery group.
UNASSIGNED: For PTC ≤5mm, both RFA and LA exhibited similar cancer control outcomes and superior quality of life on par with surgery, while minimizing complications. These findings underscore the promise of RFA and LA as potential standard treatments for small PTCs, subject to further confirmation in future studies.