关键词: Functionalized nanomaterials adrenal gland cancer endocrine related tumors nanocarriers pancreatic cancer targeted therapy thyroid cancer

Mesh : Humans Nanostructures Antineoplastic Agents / administration & dosage pharmacology Drug Delivery Systems / methods Endocrine Gland Neoplasms / drug therapy Nanoparticles / chemistry Animals Drug Carriers / chemistry Pancreatic Neoplasms / drug therapy Thyroid Neoplasms / drug therapy

来  源:   DOI:10.1080/10717544.2024.2390022   PDF(Pubmed)

Abstract:
The application of multidisciplinary techniques in the management of endocrine-related cancers is crucial for harnessing the advantages of multiple disciplines and their coordinated efforts in eliminating tumors. Due to the malignant characteristics of cancer cells, they possess the capacity to develop resistance to traditional treatments such as chemotherapy and radiotherapy. Nevertheless, despite diligent endeavors to enhance the prediction of outcomes, the overall survival rate for individuals afflicted with endocrine-related malignancy remains quite miserable. Hence, it is imperative to investigate innovative therapy strategies. The latest advancements in therapeutic tactics have offered novel approaches for the therapy of various endocrine tumors. This paper examines the advancements in nano-drug delivery techniques and the utilization of nanomaterials for precise cancer cures through targeted therapy. This review provides a thorough analysis of the potential of combined drug delivery strategies in the treatment of thyroid cancer, adrenal gland tumors, and pancreatic cancer. The objective of this study is to gain a deeper understanding of current therapeutic approaches, stimulate the development of new drug DDS, and improve the effectiveness of treatment for patients with these diseases. The intracellular uptake of pharmaceuticals into cancer cells can be significantly improved through the implantation of synthetic or natural substances into nanoparticles, resulting in a substantial reduction in the development of endocrine malignancies.
摘要:
多学科技术在内分泌相关癌症管理中的应用对于利用多学科的优势及其在消除肿瘤方面的协调努力至关重要。由于癌细胞的恶性特征,它们具有对化疗和放疗等传统治疗产生抵抗力的能力。然而,尽管努力加强对结果的预测,内分泌相关恶性肿瘤患者的总生存率仍然相当低.因此,研究创新的治疗策略势在必行.治疗策略的最新进展为各种内分泌肿瘤的治疗提供了新的方法。本文研究了纳米药物递送技术的进展以及通过靶向治疗将纳米材料用于精确癌症治疗的应用。这篇综述全面分析了联合药物递送策略在甲状腺癌治疗中的潜力。肾上腺肿瘤,还有胰腺癌.这项研究的目的是更深入地了解当前的治疗方法,刺激新药DDS的开发,并提高这些疾病患者的治疗效果。通过将合成或天然物质植入纳米颗粒中,可以显着提高药物对癌细胞的细胞内摄取,导致内分泌恶性肿瘤的发展大幅减少。
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