■人类的新兴研究已经建立了重复经颅磁刺激(rTMS)对初级体感皮层(S1)的调节作用。然而,到目前为止,这方面的研究主要集中在手和手指上,在我们对rTMS对口面部系统和言语发音器的体感感知的调节作用的理解上留下了空白。
■本研究旨在研究不同类型的theta爆发刺激-连续TBS(cTBS)的影响,间歇性TBS(iTBS),或在舌头的触觉敏锐度上伪造左侧S1的舌头表示。
■在重复措施设计中,15名志愿者参加了四个单独的会议,其中cTBS,iTBS,sham,或未在左侧S1的舌头上施加刺激。使用定制的振动触觉刺激器测量TBS对舌头的时间和空间感知敏锐度的影响。
■CTBS在刺激后16-30分钟的时间窗口显着损害了空间振幅阈值,而iTBS在同一时间窗口改进了它。iTBS的效果,然而,小于cTBS。相比之下,cTBS和iTBS对时间辨别阈值均无影响.
■本研究确立了使用TBS调节口面系统的体感感知的有效性。直接改变口腔系统的体感有可能使触觉敏锐度异常的临床人群受益。提高我们对感官系统在言语产生中的作用的理解,加强言语运动学习和康复。
■Theta爆发刺激(TBS)可以调节口面系统cTBS超过S1的舌头空间敏锐度受损TBS超过S1的舌头空间敏锐度改善。
UNASSIGNED: Emerging studies in humans have established the modulatory effects of repetitive transcranial magnetic stimulation (rTMS) over primary somatosensory cortex (S1) on somatosensory cortex activity and perception. However, to date, research in this area has primarily focused on the hand and fingers, leaving a gap in our understanding of the modulatory effects of rTMS on somatosensory perception of the orofacial system and speech articulators.
UNASSIGNED: The present study aimed to examine the effects of different types of theta-burst stimulation-continuous TBS (cTBS), intermittent TBS (iTBS), or sham-over the tongue representation of left S1 on tactile acuity of the tongue.
UNASSIGNED: In a repeated-measures design, fifteen volunteers participated in four separate sessions, where cTBS, iTBS, sham, or no stimulation was applied over the tongue representation of left S1. Effects of TBS were measured on both temporal and spatial perceptual acuity of tongue using a custom vibrotactile stimulator.
UNASSIGNED: CTBS significantly impaired spatial amplitude threshold at the time window of 16-30 minutes after stimulation, while iTBS improved it at the same time window. The effect of iTBS, however, was smaller than cTBS. In contrast, neither cTBS nor iTBS had any effect on the temporal discrimination threshold.
UNASSIGNED: The current study establishes the validity of using TBS to modulate somatosensory perception of the orofacial system. Directly modifying somatosensation in the orofacial system has the potential to benefit clinical populations with abnormal tactile acuity, improve our understanding of the role of sensory systems in speech production, and enhance speech motor learning and rehabilitation.