目的:评价孕期母亲服用抗癫痫药物对儿童发育和行为的影响。
方法:来自喀拉拉邦癫痫和妊娠登记处,连续选择了98名年龄在1½至2½y之间的儿童。选择在怀孕期间没有癫痫且未在产前接触抗癫痫药物(ASM)的母亲的孩子作为比较组。使用印度婴儿发育评估量表(DASII)和接受表达紧急语言量表(REELS)对儿童进行发育评估。使用儿童行为清单评估行为结果。
结果:在接受抗癫痫药物治疗的儿童中,表达语言能力明显延迟,比值比为2.539(95%CI1.10,5.85,P=0.026)。在使用氯巴赞的综合疗法中,表达语言能力延迟(比值比6.83;95%CI2.17,21.56,P<0.001)。此外,在同一综合疗法组中,接受性语言能力出现延迟(比值比为7.333;95%CI2.16,24.92,P<0.001).在运动和心理商域以及行为结果方面,研究组和对照组之间没有统计学上的显着差异。
结论:在暴露于ASM的儿童中发现言语延迟具有重要意义,因为有儿童言语或语言障碍史的个体可能会在心理健康方面遇到长期困难。社会福祉,和学术成果。
OBJECTIVE: To evaluate the effect of antiepileptic medications prescribed to mothers during pregnancy on the development and behavior of children.
METHODS: From the Kerala Registry of Epilepsy and Pregnancy, 98 children between the ages of 1½ to 2½ y were consecutively chosen. Children of mothers who did not have epilepsy during pregnancy and not exposed to antiseizure medications (ASMs) antenatally were selected as comparator group. Developmental assessment of the children was performed using Developmental Assessment Scale for Indian Infants (DASII) and Receptive-Expressive Emergent Language Scale (REELS). Behavior outcomes were assessed using Child Behavior Checklist.
RESULTS: A significant delay in expressive language skills was seen in children exposed to antiseizure medication with an odds ratio of 2.539 (95% CI 1.10, 5.85, P = 0.026). A delay in expressive language skills was seen in polytherapy with clobazam (odds ratio 6.83; 95% CI 2.17, 21.56, P < 0.001). Also, delay was seen in receptive language skills in the same polytherapy group (odds ratio of 7.333; 95% CI 2.16, 24.92, P < 0.001). There were no statistically significant differences between study and comparative groups in motor and mental quotient domains and behavioral outcomes.
CONCLUSIONS: The finding of speech delay in children exposed to ASMs is significant since individuals with a history of childhood speech or language disorders may experience long-term difficulties in mental health, social well-being, and academic outcomes.