Abstract：
OBJECTIVE: Evaluate pediatric auditory brainstem response (ABR) findings in children with Autism Spectrum Disorder (ASD) after the 2013 DSM-5 update.
METHODS: This was an IRB-approved, six-year retrospective chart review evaluating ABR results from pediatric patients with speech delay. Diagnosis of ASD and other neurodevelopmental abnormalities were collected for patient stratification.
METHODS: From 2017 to 2023, 148 pediatric patients with speech delay were identified through diagnosis of speech delay and underwent ABR testing. Patients were then separated into two groups: Neurotypical (N = 79) and ASD (N = 69). ABR results were obtained through chart review and waveform and interpeak latency (IPL) results were recorded. Differences in waveform and IPL results were determined via Pearson\'s chi-square test, with multivariate analysis accounting for race, sex, and age.
RESULTS: 28 patients with ASD (40.6 %) had at least one waveform/IPL prolongation. Analysis showed an increased incidence of waveform III (p = 0.028) and IPL III-V (p = 0.03) prolongation in the ASD group compared to their neurotypical counterparts. Waveform III prolongation was noted more in females with ASD (p = 0.001) than in males. No statistically significant difference when comparing race and age was found, except in the 2-3 age range (p = 0.003).
CONCLUSIONS: There were higher percentages of prolongation for all waveforms and IPLs in the ASD group versus neurotypical, though not as high as previously reported. Race and age did not appear to be factors in ABR findings though more data is needed to make clinical associations.
METHODS: This was an IRB-approved, six-year retrospective chart review evaluating ABR results from pediatric patients with speech delay. Diagnosis of ASD and other neurodevelopmental abnormalities were collected for patient stratification.
METHODS: From 2017 to 2023, 148 pediatric patients with speech delay were identified through diagnosis of speech delay and underwent ABR testing. Patients were then separated into two groups: Neurotypical (N = 79) and ASD (N = 69). ABR results were obtained through chart review and waveform and interpeak latency (IPL) results were recorded. Differences in waveform and IPL results were determined via Pearson\'s chi-square test, with multivariate analysis accounting for race, sex, and age.
RESULTS: 28 patients with ASD (40.6 %) had at least one waveform/IPL prolongation. Analysis showed an increased incidence of waveform III (p = 0.028) and IPL III-V (p = 0.03) prolongation in the ASD group compared to their neurotypical counterparts. Waveform III prolongation was noted more in females with ASD (p = 0.001) than in males. No statistically significant difference when comparing race and age was found, except in the 2-3 age range (p = 0.003).
CONCLUSIONS: There were higher percentages of prolongation for all waveforms and IPLs in the ASD group versus neurotypical, though not as high as previously reported. Race and age did not appear to be factors in ABR findings though more data is needed to make clinical associations.
摘要：
目的：评估2013年DSM-5更新后自闭症谱系障碍（ASD）儿童的听觉脑干反应（ABR）发现。
方法：这是IRB批准的，6年回顾性图表评价儿童言语延迟患者的ABR结果.收集ASD和其他神经发育异常的诊断用于患者分层。
方法：从2017年到2023年，通过语音延迟诊断确定了148名患有语音延迟的儿科患者，并进行了ABR测试。然后将患者分为两组：神经典型（N=79）和ASD（N=69）。通过图表回顾获得ABR结果，并记录波形和峰间潜伏期（IPL）结果。波形和IPL结果的差异通过皮尔逊卡方检验确定，多变量分析考虑了种族，性别,和年龄。
结果：28例ASD患者（40.6%）出现至少一个波形/IPL延长。分析显示，与神经典型对应物相比，ASD组波形III（p=0.028）和IPLIII-V（p=0.03）延长的发生率增加。女性ASD患者的波形III延长（p=0.001）比男性更多。在比较种族和年龄时没有发现统计学上的显着差异，除了在2-3年龄范围内（p=0.003）。
结论：与神经典型相比，ASD组所有波形和IPL的延长百分比更高，虽然没有以前报道的那么高。种族和年龄似乎不是ABR结果的因素，尽管需要更多的数据来建立临床关联。
方法：这是IRB批准的，6年回顾性图表评价儿童言语延迟患者的ABR结果.收集ASD和其他神经发育异常的诊断用于患者分层。
方法：从2017年到2023年，通过语音延迟诊断确定了148名患有语音延迟的儿科患者，并进行了ABR测试。然后将患者分为两组：神经典型（N=79）和ASD（N=69）。通过图表回顾获得ABR结果，并记录波形和峰间潜伏期（IPL）结果。波形和IPL结果的差异通过皮尔逊卡方检验确定，多变量分析考虑了种族，性别,和年龄。
结果：28例ASD患者（40.6%）出现至少一个波形/IPL延长。分析显示，与神经典型对应物相比，ASD组波形III（p=0.028）和IPLIII-V（p=0.03）延长的发生率增加。女性ASD患者的波形III延长（p=0.001）比男性更多。在比较种族和年龄时没有发现统计学上的显着差异，除了在2-3年龄范围内（p=0.003）。
结论：与神经典型相比，ASD组所有波形和IPL的延长百分比更高，虽然没有以前报道的那么高。种族和年龄似乎不是ABR结果的因素，尽管需要更多的数据来建立临床关联。
