碘是人体的重要矿物质,通过维持甲状腺的健康起作用。研究表明,富含碘的食物过敏(即,海鲜过敏)不是由碘本身引起的;相反,它是由其他蛋白质引起的,包括贝类和鱼类的原肌球蛋白和小白蛋白,分别。胺碘酮是一种常用的抗心律失常药,含有大量的碘。
这项研究的目的是评估药剂师的知识,态度,以及对碘过敏和胺碘酮交叉反应的误解。
2020年2月,通过向三个制药组织(沙特制药协会,科威特制药协会,和阿曼制药协会)。此外,向参加2020年迪拜国际制药和技术会议和展览会(DUPHAT)的药剂师发放了电子问卷。卡方或费希尔精确检验,在适当的时候,用于比较分类变量。采用SPSS软件进行统计分析。
数据来自66名受访者。然而,在排除不完全应答后,只有61例(92.4%)被纳入最终分析.参与者的平均年龄为35±8.48岁。大多数参与者没有制药专业认证委员会(54.1%)。此外,(41%)的参与者被许可为药剂师,拥有超过10年的初始药房执照。43(70.5%)的参与者有这样的误解:在使用胺碘酮之前应该考虑碘过敏,20/32(62.5%)仅考虑碘过敏的人认为需要使用皮质类固醇和/或抗组胺剂前用药。关于碘过敏和胺碘酮的使用,拥有委员会认证的药剂师和没有获得委员会认证的药剂师在知识方面没有显著差异.
药剂师对碘过敏和与胺碘酮交叉反应的误解很明显。实施针对药剂师的教育计划对于纠正这些误解是必要的。
Iodine is a vital mineral of the human body that acts by maintaining the health of the thyroid gland. Research has shown that iodine-rich food allergy (i.e., seafood allergy) is not caused by iodine itself; instead, it is caused by other proteins including tropomyosin and parvalbumin in shellfish and fish, respectively. Amiodarone is a commonly used antiarrhythmic agent containing a significant amount of iodine.
This study\'s objective was to assess pharmacists\' knowledge, attitude, and practices toward the misconception of iodine allergy and the cross-reactivity with amiodarone.
In February 2020, a cross-sectional study was conducted by sending out an online survey to three pharmaceutical organizations (Saudi Pharmaceutical Society, Kuwait Pharmaceutical Association, and Oman Pharmaceutical Society). Additionally, an electronic questionnaire was administered to pharmacists attending the Dubai International Pharmaceuticals and Technologies Conference and Exhibition 2020 (DUPHAT). Chi-square or Fisher\'s exact test, when appropriate, were used to compare categorical variables. The statistical analyses were carried out using SPSS software.
Data were collected from 66 respondents. However, only 61 (92.4%) were included in the final analysis following the exclusion of incomplete responses. The mean age of participants was 35 ± 8.48 years. The majority of participants did not have the Board of Pharmacy Specialties Certification (54.1%). Moreover, (41%) of participants licensed as pharmacists with more than 10 years of initial pharmacy licensure. Forty-three (70.5%) of participants had the misconception that iodine allergy should be considered before amiodarone administration, 20/32 (62.5%) of whom considered iodine allergy alone thought that premedication with corticosteroids and/or antihistamines is necessary. Concerning iodine allergy and amiodarone use, there was no significant difference in knowledge between the pharmacists who have board certification and those who did not.
Pharmacists\' misconception concerning iodine allergy and cross-reactivity with amiodarone was evident. Implementation of educational programs targeting pharmacists is necessary to correct these misconceptions.