PDF(Pubmed)
Abstract：
Shellfish is a leading cause of food allergy and anaphylaxis worldwide. Recent advances in molecular characterization have led to a better understanding of the allergen profile. High sequence homology between shellfish species and between shellfish and house dust mites leads to a high serological cross-reactivity, which does not accurately correlate with clinical cross-reactions. Clinical manifestations are immediate and the predominance of perioral symptoms is a typical feature of shellfish allergy. Diagnosis, as for other food allergies, is based on SPTs and specific IgE, while the gold standard is DBPCFC. Cross-reactivity between shellfish is common and therefore, it is mandatory to avoid all shellfish. New immunotherapeutic strategies based on hypoallergens and other innovative approaches represent the new frontiers for desensitization.
摘要：
贝类是全球食物过敏和过敏反应的主要原因。分子表征的最新进展导致对过敏原谱的更好理解。贝类物种之间以及贝类和屋尘螨之间的高度序列同源性导致高血清学交叉反应性，这与临床交叉反应并不准确相关。临床表现是即时的，口周症状占优势是贝类过敏的典型特征。诊断,至于其他食物过敏，基于SPTs和特异性IgE，而黄金标准是DBPCFC。贝类之间的交叉反应是常见的，因此，必须避免所有贝类。基于低过敏原和其他创新方法的新免疫治疗策略代表了脱敏的新领域。
