PDF(Pubmed)
Abstract：
Food allergy represents a failure of oral tolerance mechanisms to dietary antigens. Over the past few years, food allergies have become a growing public health problem worldwide. Gut microbiota is believed to have a significant impact on oral tolerance to food antigens and in initiation and maintenance of food allergies. Therefore, probiotics have also been proposed in this field as a possible strategy for modulating both the gut microbiota and the immune system. In recent years, results from preclinical and clinical studies suggest a promising role for probiotics in food allergy prevention and treatment. However, future studies are needed to better understand the mechanisms of action of probiotics in food allergies and to design comparable study protocols using specific probiotic strains, defined doses and exposure times, and longer follow-up periods.
摘要：
食物过敏代表对饮食抗原的口服耐受机制失败。在过去的几年里，食物过敏已成为全球日益严重的公共卫生问题。肠道微生物群被认为对食物抗原的口服耐受性以及食物过敏的引发和维持具有显著影响。因此,在该领域中也提出了益生菌作为调节肠道微生物群和免疫系统的可能策略。近年来,临床前和临床研究的结果表明，益生菌在食物过敏预防和治疗中具有良好的作用。然而,未来的研究需要更好地了解益生菌在食物过敏中的作用机制，并使用特定的益生菌菌株设计可比的研究方案，确定的剂量和暴露时间，和更长的随访期。
