肉瘤样肝内胆管癌(S-iCCA)是原发性肝癌的罕见变种,由于局部侵袭性扩张和频繁转移,预后不良。发病机制尚不清楚,但是理论表明上皮-间质转化,多能干细胞的双相分化,或未成熟多能癌细胞的肉瘤样再分化。慢性乙型和丙型肝炎,肝硬化,40岁以上是合理的贡献者。S-iCCA的诊断需要间质和上皮分子表达的免疫组织化学证据。早期发现和完全切除是当前的主要方法。我们报告了一例患有酒精使用障碍的53岁男性转移性S-iCCA病例,该患者接受了整体右肝叶切除术,右肾上腺切除术,和胆囊切除术.
Sarcomatoid intrahepatic cholangiocarcinoma (S-iCCA) is a rare variant of primary liver cancer with a poor prognosis due to local aggressive expansion and frequent metastases. The pathogenesis remains unclear, but theories suggest epithelial-mesenchymal transition, biphasic differentiation of pluripotent stem cells, or sarcomatoid re-differentiation of immature multipotent carcinoma cells. Chronic hepatitis B and C, cirrhosis, and age above 40 are plausible contributors. Diagnosis of S-iCCA requires immunohistochemical evidence of both mesenchymal and epithelial molecular expression. Early detection and total resection are the current mainstay approach. We report a case of metastatic S-iCCA in a 53-year-old male with alcohol use disorder who underwent en bloc right hepatic lobectomy, right adrenalectomy, and cholecystectomy.