%0 Journal Article
%T Pathologic features and clinical treatment of sarcomatoid intrahepatic cholangiocarcinoma.
%A Xie X
%A Lai N
%A Yang Y
%A Zhang J
%A Qin J
%A Sheng X
%J Intractable Rare Dis Res
%V 12
%N 4
%D 2023 Nov
%M 38024583
暂无%R 10.5582/irdr.2023.01094
%X The current study examined sarcomatoid intrahepatic cholangiocarcinoma (S-iCCA). S-iCCA was a more aggressive subtype of intrahepatic cholangiocarcinoma (iCCA). Early detection and complete resection of tumors are very important. Reported here is a case of S-iCCA, and the diagnosis and treatment of S-iCCA are discussed. The patient underwent a tumor resection and was treated with chemotherapy and molecularly targeted drugs after surgery. The clinical pathologic features and treatment of S-iCCA are discussed based on the literature. An immunohistochemical examination revealed positivity for cytokeratin 7 (CK7), CK-pan, vimentin, and CK19 and negativity for hepatocyte paraffin 1 (HepPar-1) in sarcomatoid cells. This case suggests that the particular molecular characteristics of sarcomatoid cells have great clinical diagnostic value, and comprehensive treatment of S-iCCA based on surgery is described.