PDF(Pubmed)
Abstract：
The current study examined sarcomatoid intrahepatic cholangiocarcinoma (S-iCCA). S-iCCA was a more aggressive subtype of intrahepatic cholangiocarcinoma (iCCA). Early detection and complete resection of tumors are very important. Reported here is a case of S-iCCA, and the diagnosis and treatment of S-iCCA are discussed. The patient underwent a tumor resection and was treated with chemotherapy and molecularly targeted drugs after surgery. The clinical pathologic features and treatment of S-iCCA are discussed based on the literature. An immunohistochemical examination revealed positivity for cytokeratin 7 (CK7), CK-pan, vimentin, and CK19 and negativity for hepatocyte paraffin 1 (HepPar-1) in sarcomatoid cells. This case suggests that the particular molecular characteristics of sarcomatoid cells have great clinical diagnostic value, and comprehensive treatment of S-iCCA based on surgery is described.
摘要：
本研究检查了肉瘤样肝内胆管癌（S-iCCA）。S-iCCA是一种更具侵袭性的肝内胆管癌（iCCA）亚型。肿瘤的早期发现和完全切除非常重要。这里报道的是S-iCCA的案例,并对S-iCCA的诊断和治疗进行了讨论。患者接受了肿瘤切除术，手术后接受了化疗和分子靶向药物治疗。在文献的基础上讨论了S-iCCA的临床病理特征和治疗。免疫组织化学检查显示细胞角蛋白7（CK7）阳性，CK-Pan,波形蛋白,和CK19和肉瘤样细胞中肝细胞石蜡1（HepPar-1）的阴性。此病例提示肉瘤样细胞的特殊分子特征具有较大的临床诊断价值,阐述了以手术为基础的S-iCCA综合治疗方法。
