■这项研究评估了三维打印模板(3DPT)引导的放射性种子近距离放射治疗(RSBT)的临床结果,该方法通过一种下方法治疗复发性舌根和口腔癌。
■2015-2022年31例舌底鳞状细胞癌术后放疗复发患者采用3DPT引导RSBT治疗。种子通过3DPT指导的下方法植入。本地控制(LC),总生存期(OS),评估疾病控制(DC)和生活质量(QOL)。
■中位随访时间为13.7个月。1-,3年和5年LC率为66.1%,66.1%,分别为55.1%。1-,3年和5年OS率为63.4%,33.4%,和8.3%。1-,3年和5年DC率为37.8%,26.5%,和21.2%。单因素分析显示肿瘤大小显著影响LC(P=0.031)。在多因素分析中,域外病变的存在影响DC和OS(P<0.01)。QOL在疼痛领域显著改善,吞咽,咀嚼,味道,与基线相比,治疗后的情绪。4例患者(13%)发生坏死和骨坏死。
■3DPT引导下的RSBT为口腔癌的复发性舌/底提供了良好的LC和QOL,毒性最小;此外,应注意严重的毒性。
UNASSIGNED: This study assessed clinical outcomes of three-dimensional-printed template (3DPT)-guided radioactive seed brachytherapy (RSBT) via a submental approach for recurrent base of tongue and floor of mouth cancer.
UNASSIGNED: Thirty-one patients with recurrent lingual and floor of mouth squamous cell carcinoma after surgery and radiotherapy were treated with 3DPT-guided RSBT from 2015 to 2022. Seeds were implanted through a submental approach guided by 3DPTs. Local control (LC), overall survival (OS), disease control (DC) and quality of life (QOL) were evaluated.
UNASSIGNED: The median follow-up was 13.7 months. The 1-, 3- and 5-year LC rates were 66.1%, 66.1%, and 55.1% respectively. The 1-, 3- and 5-year OS rates were 63.4%, 33.4%, and 8.3%. The 1-, 3- and 5-year DC rates were 37.8%, 26.5%, and 21.2%. Univariate analysis showed tumor size significantly affected LC (P = 0.031). The presence of extraterritorial lesions affected DC and OS on multivariate analysis (P < 0.01). QOL improved significantly in domains of pain, swallowing, chewing, taste, and emotion after treatment compared to baseline. Four patients (13%) developed necrosis and osteoradionecrosis.
UNASSIGNED: 3DPT-guided submental RSBT provided favorable LC and QOL for recurrent tongue/floor of mouth cancer with minimal toxicity; moreover, severe toxicity should be noted.